Additional Product Details

Two top gut health solutions in 1 bundle!

Now there’s an easy way to try two of Dr. Drew Sinatra’s top digestive health products in trial-size packages. LifeBiome Gut Sampler Bundle features a 7-day supply of Gut Restore Advanced probiotic and three packets of Gut Soothe Digestive Relief Complex. Gut Restore Advanced delivers the advanced support your gut microbiome needs to restore balance to your gut, while Gut Soothe—a tasty powder you simply mix with water—nourishes the gut and provides convenient on-the-go relief from upset stomach, bloating, nausea and more. This sampler bundle is the perfect way to try both products at great savings!

These plant-based LifeBiome digestive supplements were formulated by Dr. Drew Sinatra, a practicing, board-certified naturopathic physician. Dr. Sinatra looks to the health of your gut to see the health of your whole body.

You can rest assured each product is vegetarian, gentle on your stomach, and non-habit-forming, containing no artificial preservatives, flavors, colors, or sweeteners. Plus, you won’t find common allergens such as gluten, soy, or dairy in either of them.

Gut Restore Advanced Probiotic – 7-day supply

Dr. Drew Sinatra believes everyone should be taking a probiotic because your gut is the cornerstone of your overall health! Just 1 tiny vegetarian capsule of Gut Restore Advanced guarantees all of this…

11 diverse multi strains: A blend of soil-based organisms (SBOs)—coagulans MTCC 5856 LactoSpore®; yeast—S. boulardii and S. cerevisiae; and lactic acid-based strains—Bifidobacteria and Lactobacilli—helps restore balance for less gas, stomach upset, and discomfort.

Fermented whole food botanicals: A unique blend of fermented whole food botanicals—organic turmeric, organic ginger, and chlorella—come together to support the work of the probiotics. Something you won’t find in ordinary probiotics!

SMART-Release Delivery: 13 billion live probiotics get delivered to your intestines using SMART-Release technology—the most innovative system there is.

Arrives alive, ready to work: The number of live organisms on the bottle is what’s alive in your bottle even on the last day of expiration.

Gut Soothe Digestive Relief Complex – 3 convenient, on-the-go packets

Gut Soothe works hand in hand with Gut Restore Advanced for premium coverage of your digestive tract, especially for those with a sensitive stomach. Gut Soothe delivers a healthy combination of L-glutamine, ginger, and aloe along with clinically backed GutGard Licorice Extract and PreticX, a prebiotic fiber that nourishes the growth of your probiotics and healthy gut bacteria. Just one “stay fresh” on-the-go daily packet helps to:

  • Fuel your gut’s healthy bacteria with PreticX—a well-tolerated prebiotic fiber that unlike ordinary fibers, won’t upset your stomach!
  • Alleviate occasional bloating, indigestion, and stomach upset
  • Provide FAST relief for healthy bowel movements in just 5 days!

Just pour one packet into warm or cold water for soothing relief! The delicious apple-pear-ginger flavor is soothing and refreshing.

Ingredients and Dosage

1. Gut Restore Advanced

Doctor's Suggested Use: Take 1 capsule daily with a meal.

Serving Size: 1 Vegetarian Capsule
Servings Per Container: 7

Ingredient % DV
Microbiome Probiotic Blend (145 mg)
  Soil-Based Probiotics
B. coagulans MTCC 5856 (LactoSpore®),
B. subtilis (DE111®), B. clausii SNZ 1971 MTCC 5980

  Lactic Acid-Based Probiotics
B. lactis (HN019™), B. bifidum DSM 22892,
B. longum DSM 16603, L. acidophilus DSM 21717,
L. plantarum LMG P-21021, L. rhamnosus GG ATCC 53103

  Yeast-Based Probiotics
S. boulardii DBVPG 6763 (BiOOtic™),
S. cerevisiae CNCM l-3856
13 billion CFU +
Fermented Botanicals
Organic turmeric, organic ginger, chlorella
150 mg+
*Daily Value (DV) not established

Other ingredients: Hypromellose, microcrystalline cellulose, maltodextrin, rice hulls, gellan gum, silica

Precautions: Consult a health care practitioner if you are pregnant or nursing, have a serious medical condition, or use any medications.

Keep out of reach of children.

  • Gluten Free

  • Dairy Free

  • Soy Free

  • Vegetarian

DE111® is a registered trademark of Deerland Enzymes, Inc.
LactoSpore® is a registered trademark of Sabinsa Corporation.
HN019™ is a trademark of Fonterra™ Limited.
BiOOtic™ is a trademark of Gnosis SpA.
Due to the nature of these ingredients, color variation may occur.

2. Gut Soothe Digestive Relief Complex

Doctor's Suggested Use: Mix one stick pack into 8-10 fl. oz. of hot or cold water. More water may be added for your taste preference.

Serving Size: 1 Stick Pack (9 grams)
Servings Per Container: 3

IngredientAmount Per Serving% DV
Total Carbohydrates4 g1%
Glutamine (from fermentation)3 g*
Prebiotic Xylooligosaccharide (PreticX®)2.5 g*
Deglycyrrhizinated Licorice Extract
(Glycyrrhiza glabra, root) (GutGard®)
150 mg*
Aloe Vera Extract (Aloe barbadensis, inner leaf gel)100 mg*
Ginger Extract (Zingiber officinale, rhizome)50 mg*
* Daily Value (DV) not established.

Other ingredients: Malic acid, natural flavor, organic tapioca maltodextrin, silica, stevia leaf extract

Precautions: Consult a health care practitioner if you are pregnant or nursing, have a serious medical condition, or use any medications.

Due to the nature of these ingredients, color variation may occur.
This package is sold by weight and not by volume.

PreticX® is a trademark of AIDP, Inc.
GutGard® is a trademark of Natural Remedies PVT. LTD.

Science and Quality

1. Gut Restore Advanced

Soil-Based Blend

Gut Restore Advanced contains a Soil-Based Probiotic Blend consisting of three spore-forming, soil-based probiotic strains:

  1. Bacillus coagulans MTCC 5856 (LactoSpore®):

Two particular studies have shown positive effects with 2 billion CFU using LactoSpore B. coagulans. One randomized, double-blind, placebo-controlled trial with 31 participants showed that 2 billion CFU of LactoSpore® B. coagulans reduced GI discomfort compared to placebo over a 90-day study period with individuals also reporting an improvement in quality of life.1

In another randomized, double-blind, placebo-controlled trial with 40 individuals, results showed that supplementation with LactoSpore B. coagulans led to an improvement in mood and support of mental health, a reduction in gastrointestinal discomfort, and an improvement in digestive quality of life.2

  1. Bacillus subtilis (DE111®):

In a double-blind, placebo-controlled randomized study, 50 adults took 1 billion CFU of DE111 B. subtilis daily for 90 days. The subjects consuming the B. subtilis saw a significant increase in normal stools based on scoring according to the Bristol Stool Chart by days 75–90 compared to placebo. The results indicate that DE111 consumption promotes stool regularity, digestive health, improved bowel movements and healthy intestinal transit while improving occasional constipation or diarrhea.3

  1. Bacillus clausii SNZ 1971:

B. clausii is a spore-forming bacterial strain that is found in soil and in the GI tract. The strain is specifically found in alkaline nitrate-rich soil, where it converts nitrate to nitrite.

Yeast-Based Blend

Natural strains of yeast are found in the soil, on the surface of plants, and in insects and warm-blooded animals. Gut Restore Advanced provides two unique yeast-based probiotics of the Saccharomyces genera, which are normal components of the gut microbiome.

  1. Saccharomyces cerevisiae CNCM I-3856:

The Human Microbiome Project cohort conducted a study on 317 human stool samples from 147 volunteers. Results showed that S. cerevisiae was the most prominent fungal genera present in the samples with a prevalence of 92.2%. This suggests that S. cerevisiae is a commensal in the human GI tract and part of the core gut mycobiome.4

  1. Saccharomyces boulardii DBVPG 6763 (BiOOtic®): 

S. boulardii is a common fungal inhabitant in the GI tract and plays an important role in supporting intestinal health. This genome-sequenced yeast-based S. boulardii strain is called BiOOtic. BiOOtic is prestigiously produced in Sant’Antonino, Switzerland with halal, kosher, and non-GMO project verified certifications.

Lactic Acid-Based Blend

Gut Restore Advanced contains a blend of three Bifidobacteria and three Lactobacilli strains, featuring the clinically researched and genotypically documented strain Bifidobacterium lactis HN019™ (shown to be bile and acid resistant) plus Lactobacillus rhamnosus GG.

  1. Bifidobacterium lactis HN019:

One triple-blind, randomized, placebo-controlled study on 100 adults consuming either 1.8 Billion CFU B. lactis HN019, 17.2 Billion CFU B. lactis HN019, or placebo found a significant decrease in gut transit time for the B. lactis groups. Subjects in the B. lactis groups also reported significant improvement in gastrointestinal symptoms such as regurgitation, flatulence, nausea, irregular bowel movements, abdominal pain, gurgling, and constipation.5

Another 4-week randomized, double-blind, placebo-controlled study found that consumption of varying levels of B. lactis HN019 including 1 Billion CFU daily helped maintain a balanced environment in the gastrointestinal tract and the overall bifidobacteria and lactobacilli population increased as well.6

  1. Bifidobacterium bifidum BB01 (DSM 22892)
  2. Bifidobacterium longum BL03 (DSM 16603)
  3. Lactobacillus acidophilus LA02 (DSM 21717)
  4. Lactobacillus plantarum LP01 (LMG P-21021)
  5. Lactobacillus rhamnosus GG ATCC 53103

Fermented Botanical Blend

The Fermented Botanical Blend includes a trusted brand of fermented botanicals called FermaPro® which works in conjunction with the Gut Restore Advanced probiotic blend to provide complete and comprehensive support for and coverage of the microbiome. The fermentation process used in the Fermented Botanical Blend helps enrich foods by fermenting them with beneficial bacteria, a practice that dates back thousands of years.7

UNIQUE DELIVERY TECHNOLOGY: DRcaps® vegetarian capsules

DRcaps vegetarian SMART-Release capsules have been scientifically studied to be acid-resistant and protect against early disintegration in the stomach. In 2013, an independent research laboratory (Bio-Images Research, in Glasgow, Scotland) conducted a human in-vivo study to evaluate the disintegration behavior of the DRcaps in human subjects.

Approximately 30 minutes after consuming a small meal, eight subjects swallowed one DRcaps filled with radio label and 150 mL of room temperature water. Gamma scintigraphy images showed that disintegration occurred approximately 45 minutes later than the immediate release capsules of approximately 5 minutes. The mean time of onset release was 52 minutes, right as the capsules were about to leave the stomach. Most of the release completion occurred in the small intestine. 8

In a separate in-vitro disintegration test of DRcaps with simulated gastric fluid of pH 1.2, capsules resisted rupture for at least 30 minutes (DRcaps Capsules Performance Characteristics). This simulation of gastric and intestinal fluids proved that the capsules would release at different points based on the surrounding pH level.8

1 Majeed M, et al. World J Microbiol Biotechnol. 2016; Apr;32(4):60.
2 Majeed M, et al. Food & Nutrition Research. 2018; 62. 10.29219.
3 Cuentas A M, et al. J Prob Health 2017; 5: 189.
4 Nash AK, et al. Microbiome. 2017; 5. 10.1186.
5 Waller PA, et al. Scandinavian Journal of Gastroenterology. 2011; 46. 1057–64.
6 Ahmed M, et al. The Journal of Nutrition, Health & Aging. 2007; 11. 26–31.
7 Chilton, SN. Nutrients 2015; 7. 390–404.
8 Unpublished. DRCaps® Capsules Achieve Delayed Release Properties for Nutritional Ingredients in Human Clinical Study. 2014.

2. Gut Soothe Digestive Relief Complex

Glutamine: an amino acid and chief building block for the epithelial cells that line the intestinal wall. Laboratory studies suggest glutamine may help promote the tight junctions between cells of the intestinal wall, thereby supporting the health of the intestinal barrier.1 A healthy intestinal barrier allows beneficial nutrients to pass through into the bloodstream for overall good health.2

PreticX® XOS Fiber: A unique source of non-digestible fiber from non-GMO corn. Provides beneficial gut bacteria with energy, thereby promoting the growth of beneficial gut flora, particularly bifidobacteria.3,4,5

  • Research suggests XOS strongly fosters the growth of bifidobacteria, one of the beneficial bacteria in the gut.4,5
  • Unlike other sources of plant fiber, it requires a lower dose for benefits and has been found to be better tolerated by not promoting excessive cramping, gas, or bloating.4

GutGard™: This special form of licorice extract is shown in clinical research to reduce occasional bloating, belching, and feeling of fullness and nausea after meals.6 It provides antioxidant protection from free radicals and oxidative stress.7

  • In a double-blind, placebo-controlled study, 50 participants who took GutGard for 30 days saw a reduction in bloating, belching, and nausea as well as reduced feelings of fullness after meals.6
  • Animal studies show it supports the gastric mucosal lining and that it balances stomach acid production.7

Ginger Extract: works through the digestive tract to soothe the gut. And, laboratory studies suggest it helps support a healthy inflammatory response.8

  • Contains unique phenol and gingerol compounds which support a healthy inflammatory response in laboratory studies.

Aloe Vera Extract: supports overall gastrointestinal health.9,10 It has traditionally been used for its soothing properties.

  • Contains antioxidant polyphenols that provide protection from oxidative stress and free radicals.11,12,13

1 Li N, Neu J. J Nutr. 2009;139(4): 710–14.
2 Scheppach W, et al. Gut 1996;38(6): 878–85.
3 Yang J, et al Frontiers in Physiology 2015;6: 1–11.
4 Finegold SM, et al. Food & Function 2014;5: 436–45.
5 Chung Y-C, et al. Nutr Res. 2007;27(12): 756–61.
6 Raveendra KR, et al. Evid Based Comp and Alt Med. 2012;2012: 1–9.
7 Mukherjee M, et al. Indian J Exp Bio. 2012;2012: 1–9.
8 Breemen RB, et al. Fitoterapia 2011;82(1): 38–43.
9 Pogribna M, et al. Letters in App Microbiol. 2008;46(5): 575–80.
10 Keshavarzi Z, et al. Avicenna J Phytomed 2014; 4(2): 137–43.
11 Nejatzadeh-Barandozi F. Organic and Medicinal Chemistry Letters 2013;3(1): 1–8.
12 Prueksrisakul T, et al. J Comp and Integ Med. 2015;12(2): 159—64.
13 Rajasekaran S, et al. Pharmacological Reports 2005;57: 90–96.

Product Quality

  • Manufactured to exacting standards using highest quality raw materials
  • Produced in accordance with our strict Standard Operating Procedures (SOPs) that meet or exceed those set by the FDA’s Good Manufacturing Practices
  • Every batch tested to verify purity and potency specifications are met
  • Quality assured with our Triple-Testing Philosophy™
  • Backed by our 100% satisfaction guarantee

Product reviews and ratings are provided for informational purposes only and reflect solely the views and opinions expressed by the individual contributors and not those of Healthy Directions LLC. Healthy Directions LLC neither verifies nor endorses any claims made in these reviews and ratings.