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Unlike many pain creams, Instaflex® Pain Relief Cream is doctor developed, clinically studied, and is formulated with an exclusive oxygenated oil that works quickly to:
*Instaflex Pain Relief Cream has been clinically shown to relieve pain nearly twice as well as a comparable menthol-only cream (1.25% concentration). Taylor R. et al. Pain Practice 2012;12(8):610‑19.
In Biblical times, stories abounded of a mysterious oil used by ancient healers. It was said to be a precious and wonderfully soothing elixir. Traditionally, this healing oil was made by leaving an essential oil in an open vat for 20 years, allowing the sun’ rays to infuse the oil with oxygen.
Today, modern science has rediscovered the power of hyper-oxygenated oil, and the oxygenation process has been shortened to just 3 days. Athletes in Europe have been using this oil for years, but it took leading pain expert Dr. Joseph Pergolizzi to bring it home to the U.S. and combine it with soothing menthol to create the formula for new Instaflex Pain Relief Cream.
A randomized double-blind, controlled study found that Instaflex Pain Relief Cream was nearly 2x as effective at relieving pain as a comparable menthol-only rub. Adult subjects using Instaflex reported improvements in pain, mobility and flexibility.
*Instaflex Pain Relief Cream has been clinically shown to relieve pain nearly twice as well as a comparable menthol-only cream (1.25% concentration). Taylor R. et al. Pain Practice 2012;12(8):610‑19.
Instaflex® Oxygenated Pain Relief Cream vs. Menthol-Only Pain Cream
“I have been suffering from increasing arthritis pain! However, since I have been using Instaflex Pain Relief Cream, changes have occurred that are almost miraculous to me. This cream really works! I was unable to sleep due to shoulder pain, but after applying the Instaflex Cream as instructed I can now sleep pain-free from that area.
All in all, Instaflex Cream has made me a new and improved person! I am able to regain my life and enjoy the activities that were previously denied due to my pain levels.”*
—Darlene T., Retired Feature Editor, The Houston Post
“As a Realtor, I show properties to potential clients, which requires me to go up and down stairs. Three-story townhouses are tough on the knees (I grab the rail immediately). My joint pain is in my knees and I have had it for about three years. I walk two miles five days a week to exercise, but it does not seem to help.
I have really enjoyed Instaflex Pain Relief Cream. I walk a lot and find that Instaflex Cream alleviates the pain. I use it both before and after. I've used many other products, but Instaflex Cream works better. And I find it is better to use more—the more I use, the better it works. I love my Instaflex.”*
—Miriam F., Age 64, Realtor
“I'd learned to grin and bear my knee pain, but hated to ‘two-step’ it down the stairs in the morning. Now that I’ve found Instaflex Pain Relief Cream, the pain is relieved.”*
—Jim M., Age 63, U.S. Special Ops Trainer
*Instaflex Pain Relief Cream is designed for temporary relief of minor aches and pains, showing a 59.5% improvement after 7 days of use.
Instaflex Pain Relief Cream was formulated by the internationally recognized Dr. Joseph Pergolizzi, an actively practicing physician, and highly sought-after pain relief instructor, treating patients in his advanced Florida practice. Just some of the highlights of his career include…

“My view is that topical pain-relieving creams are very effective at controlling pain—and are a key part of my multimodal pain treatment plan for many of my patients. And unlike other pain relief creams, Instaflex contains less menthol because I favor a less-is-more philosophy when treating pain. The minimum effective dose in Instaflex Pain Relief Cream, combined with a non-GMO, oxygenated oil, delivers maximum results while limiting the unwanted side effects that can come with higher doses.”
Chief Medical Advisor for Instaflex