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By Julian Whitaker, MD
We may be living longer than ever before, but it’s how you live these years that makes all the difference. And that’s where a rare mega antioxidant called Pycnogenol is helping to change everything.
Though it’s not yet a household name, Pycnogenol (pic-noj-en-all) is one of the most well-researched supplements in the world. It’s been shown to help with everything from ears and eyes to the health of your joints, skin, and brain.
As I write this, extensive research continues on Pycnogenol’s potential benefits for blood sugar, fitness, and so many more quality of life issues.
The surprising part is that Pycnogenol is not a nutrient at all. It’s a compound of mega antioxidants discovered in a seemingly unusual source, the bark of French maritime pine trees.
Pycnogenol’s stunning antioxidant make-up gives you procyanidins, bioflavonoids, polyphenols, phenolic acids, and catechins, just to name a few. Many of these powerhouse antioxidants are difficult to get in our modern diets.
Even if you ate the healthiest foods on earth, it’s very difficult to get all the nutrients and antioxidants you need from your diet alone. But that’s why the antioxidant power in one tiny Pycnogenol capsule is so exciting. It’s hard to believe how much it can do for you until you see the science…
How can one tiny ingredient do so much? Because Pycnogenol works in an unusual way...
It doesn’t target a specific organ—instead, it works through your entire blood vessel system—which means a wonderful, wide range of health benefits.

Think of your blood vessels as a superhighway. Every second of every day, this complex highway carries oxygen and nutrient-rich blood to every part of your body, from your brain to your toes. Maintaining this superhighway is one of the foundations of a healthy life.
Pycnogenol works as a powerful antioxidant and regulates proper inflammatory response through every blood vessel in your body. It supports and strengthens your miles of blood vessels—even supporting the microvessels in your eyes!
I first began writing about Pycnogenol 20 years ago, and since then the research has exploded. Pycnogenol’s wide-ranging health benefits are based on:
There is no other antioxidant in existence with this level of scientific and clinical research.
Julian Whitaker, MD
It works like gangbusters, but only if you take the clinical form of Pycnogenol. Be careful, there are many French maritime pine extract supplements cropping up these days. But there is only one patented, researched Pycnogenol.
That’s why I only use and recommend Clinical Grade Pycnogenol. It contains only premium, researched Pycnogenol®—the only one tested through decades of science and clinical trials.
Different health concerns require different doses. That’s why my Clinical Grade Pycnogenol comes in versatile mini-capsules which allows you to adjust your dose to suit your personal health needs—whether it’s your ears, eyes, blood pressure, or all three.

Motivated by the belief that “no patient is too sick to recover their health,” Dr. Whitaker’s philosophy combines therapeutic lifestyle changes, targeted nutritional support, and other cutting-edge natural therapies to promote vibrant health.
Founded the Whitaker Wellness Institute medical clinic and wellness center in Newport Beach, California, in 1979. Until its closing in 2018, Dr. Whitaker's clinic was known worldwide for turning around “hopeless” medical cases.
Developed dozens of serious science-based, supplement formulas which have helped people achieve optimal wellness.
Author of over 13 top-selling books including: Reversing Diabetes; Reversing Heart Disease; Guide to Natural Healing; and How to Shed 10 Years in 10 Weeks.
Featured on major television news programs which include: The Today Show, Good Morning America, Larry King Live, CNN, 48 Hours, Dateline NBC, and MSNBC
Widely quoted as a natural medical expert in numerous publications like The New York Times, Los Angeles Times, Washington Post, TIME magazine, and many others.
Editor-in-Chief of Health & Healing newsletter—a monthly publication which has reached over 2 million people and medical professionals since it began in 1991…the same publication TIME magazine honored for being one of the best physician-edited newsletters.
Given the First Amendment Freedom Award for championing medical truth.
Wouldn't you like to be one of those people who travel the world, climb moutains, and stay sharp as a tack well into your 80, 90s and beyond?
What might surprise you is that one of the best ways to stay healthy and live well is to take care of your blood vessel system. Maintaining smooth, healthy blood vessels supports every part of your body, not just your heart.
One of the keys to Pycnogenol’s power is its ability to strengthen and support the lining of your blood vessels—all 60,000 miles of it!
It maintains and helps pave the way for healthy, safe blood flow throughout your body to all of your systems, including your extremities. This in turn fuels the health of your brain, vascular system, eyes, ears, skin, and joints.

You have 60,000 miles of blood vessels. If all the blood vessels in your body were laid end to end, they would reach about 60,000 miles. They are so long, they could circle the globe.
Nearly 2,000 gallons of oxygen- and nutrient-rich blood runs through your blood vessels every single day. Over the course of a lifetime, your blood vessels will carry about a million barrels of blood throughout the body.
Blood vessels must work as a team including your arteries, veins, and capillaries. Arteries take blood away from your heart, veins take blood back to your heart, and capillaries work between veins and arteries and supply your tissues with blood.
Unlike most stand-alone antioxidants, Clinical Grade Pycnogenol possesses three properties which work synergistically. This helps explain its remarkable, versatile health benefits...

One of the main reasons we age is due to nasty little molecules called free radicals. They come at us from the foods we eat, the water we drink, and the air we breathe—they are virtually unavoidable. Over time, free-radical damage builds and causes oxidative damage to the cells and tissues of your body—it’s the essence of aging.
The vast antioxidant blend in Clinical Grade Pycnogenol results in one of the most potent scavengers of free-radicals ever studied. It helps to mop up free radicals before they cause oxidative damage.
Inflammation is a necessary and natural function. The key is to maintain a normal inflammatory response. Your body sends inflammatory signals to a troubled site in your body in order to heal and repair. Once the job is done, the inflammation signals turn off. But what you don’t want is for the signals to remain on—this is where the trouble starts.
Pycnogenol has the unique ability to help regulate the on/off switch of inflammation. It promotes a normal inflammatory response.
Nitric oxide (called NO for short) is naturally produced in the innermost layer of cells that line your blood vessels (the endothelium). NO signals blood vessels to relax and helps keep your blood moving. It’s the key factor that determines the health of your vascular system. The bottom line—you want your NO levels to stay nice and plentiful.
Clinical investigations show Pycnogenol promotes healthy production of nitric oxide, which optimizes blood flow.
Supporting your vision is a vital part of maintaining independence and quality of life as we age. It’s incredibly important to address the health of your lenses, retinas, and micro circulation in the eyes.
Clinical Grade Pycnogenol is a simple way to support the health of your eyes. Five clinical studies with over 1,000 patients demonstrated Pycnogenol supported healthy retinal blood vessels and microcirculation in the retina.
In a three-month study, individuals who took 150 mg of Pycnogenol per day had a 30% greater increase in retinal blood flow compared to those taking the placebo. Pycnogenol also improved visual acuity.

There are two important ways Clinical Grade Pycnogenol helps your brain and cognitive function. First, it promotes blood flow—which is VITAL for the health and well-being of your brain. But Pycnogenol increases levels of nitric oxide, and this is great for mental sharpness.
So when you take Pycnogenol, science shows it supports your mental performance, attention, and overall cognitive function. It’s even been shown to improve mood!
In a recent Pycnogenol study in the Journal of Neurosurgical Sciences with participants ages 35 - 55, 150 mg a day of Pycnogenol was shown to support mental performance, attention; improve mood, and reduce oxidative stress by 30%.
Scientific interest in pine bark extract was stimulated by French explorer Jacques Cartier’s 1535 expedition to find a northwest passage to China. During the trip, most of the men got sick from a “mysterious epidemic.” And many began to die.
Cartier turned to Native American medicine men who told him to boil the bark and needles from a certain pine tree in water and have his men drink it. The men rapidly recovered. The sickness these men suffered from was scurvy.

Hundreds of years later, scientists aware of the history behind the expedition became intrigued. They wanted to find out why a tree bark cured these men.
It began in the 1960's when the chairman of Horphag Research Charles Haimoff initiated a visionary concept of what he called “healthy aging.” In his Berlin-based laboratories, he developed a unique substance extracted from the bark of the French maritime pine tree—today called Pycnogenol.
Through the years, the unique extraction process has been patented by Horphag Research, as have uses of Pycnogenol including its use as an antioxidant and for improving blood circulation.
To date, the Horphag company has invested millions of dollars into clinical trials and research, and has been highly praised and won numerous awards for its commitment to science, innovation, and quality.
The French maritime pine tree from which Pycnogenol is extracted grows along the Bay of Biscay in the coastal region of Southwest France.
The trees are grown without pesticides or herbicides in a totally unspoiled environment and sustainable forest. Trees are never cut down specifically to make the ingredient—the extraction process is done by using products of the timber industry in southwest France—and by law the timber companies replant a tree whenever one is cut down.
Many people don’t realize how closely healthy ears are linked to healthy blood vessels. You need a robust blood supply to bring oxygen and nutrients to your cochlea—the inner-ear organ responsible for hearing.
And that’s what Pycnogenol does...it improves circulation to your inner ear. This also makes it especially helpful for a common, annoying ear symptom...
Whether you describe it as buzzing, hissing, or whistling, occasional “ringing in the ears” is a common and annoying problem which is often related to normal aging.
Clinical Grade Pycnogenol has been shown to improve microcirculation to the cochlea, which helps reduce occasional ringing and support the overall health of your inner ear.
Ear Health
In a six-month study at the Chieti-Pescara University in Italy, a group of individuals took 150 mg/daily of Pycnogenol or a placebo.
Circulation itself is the action of blood moving through your cardiovascular system, in other words, blood flow. This is when blood is pumped from your heart through your blood vessels to your brain, organs, and limbs—and then back around again.
The key? You want it to be easy for your blood to flow everywhere so it can deliver much-needed oxygen and nutrients.
There’s no doubt that keeping your cardiovascular system healthy (this means your heart and blood vessels) is key for a lifetime of vitality, physical strength, and overall well-being.
A simpler way to put it...a healthy cardio system goes hand-in-hand with a long, vibrant life! Clinical Grade Pycnogenol is simple way to give yourself an extra edge...
It not only helps mop up free radicals throughout your entire cardiovascular system and support proper inflammatory response, it helps open up blood vessels thanks to its ability to improve nitric oxide production. The result is healthy circulation and excellent support for blood pressure.
While circulation is the movement of blood through your cardiovascular system, blood pressure is the actual force the blood has as it pushes against the sides of your blood vessels.
You want it to be nice and normal, so your heart does not need to pump harder, and your arteries are not under strain.
In a randomized, double-blind, placebo-controlled study, individuals were given 125 mg of Pycnogenol or a placebo daily. Supplementation with Pycnogenol helped promote healthy blood pressure levels, with statistically significant reductions in markers of blood vessel constriction. Statistical significance was related to a lowering in plasma endothelin-1 biomarker.
Clinical Grade Pycnogenol enhances circulation and promotes normal blood pressure by supporting nitric oxide production. It is believed this is achieved through nitric oxide production.


It’s called “Economy Flight Syndrome,” and it’s been attracting a lot of attention in recent years. If you’ve ever been in a cramped position for hours at a time on a long flight (or long car ride), and harnessed in with a tight seat belt, you know how it feels.
Next time you travel for long periods of time, make Pycnogenol your travel companion! Take it before, during, and after your trip, and it will support healthy circulation and blood flow all over, including your crammed legs!
In a study examining “Economy Flight Syndrome,” participants received 200 mg of Pycnogenol, 2-3 hours before the flight, 200 mg approximately 6 hours later, and 100 mg the following day. Compared to placebo, the Pycnogenol flight group had significant healthier leg circulation.
There’s no getting around it. Our joints and cartilage are subject to wear and tear every day. And as we age, it adds up. In fact, the majority of people over 65 feel it...whether it’s stiff knees or fingers, an aching back, or sore hips.
Clinical Grade Pycnogenol not only helps improve joint comfort, it also promotes healthy joint function thanks to its abilities to support a normal inflammatory response.
Research shows significant improvements...
Remember, Pycnogenol helps regulate inflammation signals—and these are the same signals that can make your joints feel achy and stiff.
First, Pycnogenol inhibits inflammatory COX enzymes, including both the COX-2 and 5-LOX. And it’s been shown to lower another inflammatory signal called C-reactive protein (CRP). CRP is produced in the liver and its levels rise in response to inflammation.
By lowering CRP and inhibiting COX enzymes, you’ll feel improvement in both your joint comfort and flexibility.
In a double-blind, placebo-controlled study, individuals taking 200 mg/daily of Pycnogenol had significant improvements in joint discomfort, function, and performance on a treadmill.
In another clinical study, Pycnogenol lowered the inflammatory marker CRP by 72%, while only an 8% reduction was observed with the placebo.
One of the most unexpected surprises of Clinical Grade Pycnogenol may be its great benefits for skin. Research shows it helps:
In all makes perfect sense when you remember how Pycnogenol works. First, it promotes healthy circulation, delivering oxygen and nutrients to all of your systems, including your biggest organ—your skin! Among other factors, keeping your skin healthy depends on robust blood flow and oxygenation.
Works from the inside out...
Plus, Pycnogenol's potent antioxidant make-up fights oxidative stress and promotes proper skin elasticity and smoothness. It even boosts hyaluronic acid—the moisturizing component of collagen—that starts to decrease after age 30.
Researchers discovered one more unique property of Pycnogenol that explains its benefits for skin. Pycnogenol actually binds to collagen and elastin acting as a stabilizer of sorts. This helps to protect collagen and elastin, resulting in increased skin elasticity and smoothness.
According to findings from a recent study published in Skin Pharmacology and Physiology, in 12 weeks of supplementation, Pycnogenol boosted skin elasticity, skin hydration and hyaluronic acid production.
Healthy Blood Sugar Levels
According to research, Pycnogenol may help normalize blood sugar levels by slowing the absorption of carbohydrates and consequently lowering the glucose load of the blood stream
Sexual Wellness
For men to maintain healthy sexual function, we must have good circulation. Simply put, erections depend on healthy blood flow. And Pycnogenol’s ability to support production of nitric oxide (NO) is the key to its sexual health benefits. Remember, NO signals blood vessels to relax which promotes healthy blood flow—and this includes the penis. Stay tuned, more research is underway investigating Pycnogenol and how it helps women’s sexual health, too.
Varicose and Spider Veins
You will typically see them on your legs and feet, though they can really occur anywhere, including the tiny capillaries in your face.
Promising and growing research shows Pycnogenol can help. The main reason is due to its strengthening effect on the vein wall, which promotes healthy veins on the inside and their appearance on the outside.

Dr. Whitaker’s Clinical Grade Pycnogenol contains the only French maritime pine bark extract shown in extensive human clinical studies to have remarkable benefits for a wide variety of health needs. For the sake of your health, beware of imitations.

Safe to take: Pycnogenol is one of the most well-researched supplements in the world and has passed extensive and rigorous safety tests. Toxicity results have demonstrated that Pycnogenol is safe, even at high doses for long periods of time.
Environmentally-friendly: Pycnogenol comes from one particular source and is a renewable ingredient. Green practices are strictly followed before, during, and after manufacturing.during, and after manufacturing.

It’s rare when such a small, easy change can improve your life in so many ways. That’s what makes Pycnogenol so unique and powerful.
Remember, this tiny mega-antioxidant supports and strengthens all of your blood vessels, from your brain to your toes. And it’s one of the most well-researched supplements in the world with volumes of clinical evidence to support it.
Just remember to take the right dose for you and use only patented, clinically studied Pycnogenol. My Clinical Grade Pycnogenol® comes in versatile mini-capsules so you can customize your dosage and you’ll always know you’re getting the real stuff!
The team at Healthy Directions, the folks who make my Clinical Grade Pycnogenol available, are the best in the business. They cover every bottle with a 100% money-back guarantee. You’re thrilled, or it’s FREE—no strings attached, no questions asked.
I believe that once you start taking Pycnogenol, you’ll want to make it a regular (and easy) part of your quest to stay healthy, strong, and vital for life. And that’s what it’s all about—the quality of life you enjoy for your entire life!
To your good health,
Julian Whitaker, MD
You’ll get this at-a-glance chart with every order of Clinical Grade Pycnogenol!
If you’re not thrilled for any reason, you can return Clinical Grade Pycnogenol for a full refund—you can send back empty bottles and still get a 100% refund! You have a full 90 days to try it out. No questions asked…No strings attached…Really!
Healthy Directions, the manufacturer of Clinical Grade Pycnogenol, adheres to exceptionally high quality standards that go well beyond industry norms. We have maintained our spotless safety record for over 20 years. Our Triple-Testing Philosophy™ ensures that Clinical Grade Pycnogenol is manufactured under stringent quality controls that even exceed the requirements of the FDA for dietary supplements, including:
1—Rigorous Screening of Raw Materials in compliance with current Good Manufacturing Practice (GMP) to assure the identity, quality, purity, and potency of every batch of Clinical Grade Pycnogenol.
2—100% Finished Goods Batch Testing to ensure that Clinical Grade Pycnogenol meets label claim and purity specifications. Extensive testing is combined with state-of-the-art manufacturing and strict inspections at critical points throughout the production process.
3—Independent Laboratory Testing to confirm that Clinical Grade Pycnogenol meets purity and potency specifications for optimal efficacy.
