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The Gold Standard for Blood Sugar Health Combined with Effective Microcirculation Support
Maintaining healthy blood sugar or keeping your glucose levels steady is, of course, critical to your overall health. One reason is that glucose can interact with proteins and create advanced glycation end products (AGEs). Keeping AGEs in check is a vital part of keeping nerve function, circulation, and other critical physiological processes healthy.
That's what makes this supplement combo so valuable for healthy blood sugar and overall health. The ingredients in Berberine+ GlucoGold help maintain blood sugar levels already in the normal range, as well as support the normal response of insulin to blood sugar, while Complete Neurovascular Support protects nerves and defends against the formation of AGEs.
Clinical study shows significant support for blood sugar health
A double-blind, placebo-controlled clinical study showed that Berberine+GlucoGold provides significant support for maintaining blood sugar levels already in the normal to high-normal range. Plus, the clinical study showed the unique combination in Berberine+ GlucoGold also provides support for healthy total and LDL cholesterol levels1—especially important for folks already concerned about blood sugar.
Key DIo marker shows improvement by 88%
If you haven’t heard about this important marker used by researchers, DIo (oral Disposition Index) is a key measure to assess how well the beta cells in your pancreas respond to blood sugar. These beta cells create insulin so your body can turn sugar into energy, and store insulin so your body can respond quickly to dietary increases in blood sugar—both important functions to maintain a proper blood sugar balance.
During the Berberine+ GlucoGold clinical study, it was shown that, compared to the placebo, the DIo marker improved by over 88%, a remarkable increase. This shows how well Berberine+ GlucoGold supports the beta cells in your pancreas so they can properly respond to glucose in the bloodstream—which is incredible for pancreatic health.
Enjoy premium blood sugar support with this unique trio of researched ingredients
The Berberine+ GlucoGold clinical study also confirmed the individual research results of its three premier ingredients—berberine, Crominex® 3+, and cinnamon.
1,500 mg BERBERPURE™ BERBERINE helps maintain healthy blood sugar
Even though it was originally used in ancient Chinese medicine for digestion, current research has discovered that concentrated berberine has an amazing ability to impact blood sugar levels. Berberine facilitates the entry of glucose from your blood into your cells by enhancing the function of your AMPK proteins. AMPK helps regulate glucose uptake and the synthesis of glucose transporters—which move glucose out of your blood and into your cells, where it is converted to energy. Plus, it has been shown to support GI tract health and abdominal comfort.
400 mcg CROMINEX 3+ CHROMIUM clinically studied for improved bioavailability
Chromium, an essential trace element required for normal fat and carbohydrate metabolism, enhances the function of the insulin receptors on your cells, impacting their sensitivity. This unique, clinically studied chromium blend includes optimized chromium with the addition of Capros® Amla extract and PrimaVie® purified Shilajit extract, for superior bioavailability. And now, the latest research shows improved results with a 400 mcg dose of Crominex 3+ versus 200 mcg daily.
1,000 mg CINNAMON (Cinnamomum cassia) supports normal insulin sensitivity
Research demonstrates that cinnamon—an ingredient Dr. Whitaker has recommended for years to maintain healthy blood sugar—can actually promote the absorption of berberine in the intestines and increase its concentration in the blood.2 In other words, the bioavailability of berberine increases! What’s more, Cinnamomum cassia also has its own unique benefits: it supports the function of your body’s natural insulin, the “vehicle” that delivers glucose to your cells. It’s been long used to help maintain blood sugar levels.
Warm, Comfortable Fingers and Toes Starting in Just 30 Minutes
Many individuals with blood sugar issues have concerns around their levels of nerve sensation and circulation in their extremities, especially the legs and feet. This sometimes develops when there is excess oxidative stress on the body.
What contributes to circulatory health?
When blood glucose levels remain elevated for an extended time, oxidized “sticky” sugar molecules can attach to protein molecules—a process called glycation. Glycation of protein molecules creates cross-links between adjacent protein molecules. This cross-linking creates new protein structures called advanced glycation end products (AGEs). Keeping AGEs in check is a vital part of keeping nerve function, circulation, and other critical physiological processes healthy.
Three ingredients tackle AGEs and support your entire neurovascular system
- Award-winning Oligonol® supports microcirculation—sending blood to your fingers and toes. In addition to inhibiting production of AGEs, proper neurovascular function depends on ample amounts of nitric oxide, a compound in the arteries that helps your blood vessels to dilate as they should. Scientists have discovered that Oligonol, a highly bioavailable form of lychee fruit, contains special antioxidants called proanthocyanidins. Proanthocyanidins help activate the nitric oxide pathways in your blood vessels—stimulating much-needed blood flow to all your extremities…helping warm your fingers and toes.
- Benfotiamine helps to “deactivate” AGEs so your nerves can work properly.Scientists discovered a special form of vitamin B1 called benfotiamine that can help inhibit AGEs. Benfotiamine has a unique structure that allows it to pass directly through your cell membranes and be delivered straight into your cells. Once inside, in vitro studies have suggested benfotiamine works by activating an enzyme that inhibits the formation of AGEs to support healthy nerve function. The study results are impressive…
- In a six-week clinical study, individuals experiencing discomfort in their legs who took benfotiamine along with vitamins B6 and B12 experienced significant improvements at both three and six weeks.3
- A three-month study pairing benfotiamine and vitamin B12 gave participants significant relief by day 20—with sustained relief until the end of the study.4
- In yet another study, participants with nerve-related discomfort who took benfotiamine daily for three weeks experienced statistically significant improvements.5 Complete Neurovascular Support includes the optimal 300 mg dose of benfotiamine, along with vitamins B6 (50 mg) and B12 (250 mcg), which work together with benfotiamine for powerful neurovascular support.
- Alpha lipoic acid helps protect your neurovascular system from oxidative stress. The final ingredient in Complete Neurovascular Support is alpha lipoic acid (ALA). ALA is a powerful antioxidant which helps protect your nerves and blood vessels from oxidative stress. A randomized, controlled trial measured the effect of oral ALA supplementation on “flow-mediated dilation”— a critical heart health marker used to measure circulation. The study showed that supplementing with 300 mg of ALA a day —the exact amount in Complete Neurovascular Support—for four weeks improved blood flow!6
When taken together with Berberine+ GlucoGold, this combination is a great way to help keep your blood sugar levels healthy and support proper circulation and nerve function throughout your body.
1 Healthy Directions. Berberine+ GlucoGold and its effects on glucose metabolism. 2016. Unpubl.
2 Huang Z, et al. J Huazhong Univ Sci Technolog Med Sci. 2011;31(3):379–83.
3 Winkler G, et al. Arzneimittelforschung 1999;49(3):220–24.
4 Simeonov S, et al. Folia Medica (Plovdiv). 1997;34(4):5–10..
5 Haupt E, et al. Int J Clin Pharmacol Ther 2005;43(2):71–7.
6 Sola S, et al. Circulation. 2005;111:343–8.
Ingredients and Dosage
Doctor's Suggested Use: Take 3 tablets daily; 1 before each meal.
Serving Size: 1 Tablet
Servings Per Container: 90
|Ingredient||Amount Per Serving||% DV|
|Calcium (as dicalcium phosphate)||20 mg||2%|
|Chromium (as Crominex® 3+ chromium stabilized with Capros® standardizedAmla Extract (fruit) and PrimaVie® purifiedand standardized Shilajit)||133 mcg||380%|
|Berberine Hydrochloride (BerberPure™)||500 mg||*|
|Cinnamon (as Cinnamomum cassia, bark)||333 mg||*|
|*Daily Value (DV) not established.|
Other ingredients: Magnesium stearate, croscarmellose sodium, microcrystalline cellulose, silica, hydroxypropyl methylcellulose, polydextrose, titanium dioxide, talc, maltodextrin, medium chain triglycerides, riboflavin (color)
Precautions: Consult a health care practitionerbefore use if you are on insulin or are hypoglycemic,are pregnant or nursing, have a serious medicalcondition, or use any medications.
This product contains natural ingredients; color variations may occur.
Crominex® 3+, Capros® and PrimaVie® are registered trademarks of Natreon, Inc.
BerberPure™ is a trademark of Healthy Directions LLC.
Complete Neurovascular Support
Doctor's Suggested Use: Take 2 capsules daily. For additional support, take 2 capsules twice daily.
Serving Size: 2 Capsules
Servings Per Container: 30
|Vitamin B6 (as pyridoxine HCl)||50 mg||2,941%|
|Vitamin B12 (as cyanocobalamin)||250 mcg||10,417%|
|Alpha Lipoic Acid||300 mg||*|
|Oligonol® Proprietary Blend Lichee Extract (fruit), Green Tea Extract (leaf)||50 mg||*|
|*Daily Value (DV) not established.|
Other ingredients: Microcrystalline cellulose, gelatin, silica, magnesium stearate
Contains: Lichee Nut
Precautions: Consult a health care practitionerbefore use if you are pregnant or nursing, have a serious medicalcondition, or use any medications.
Keep out of reach of children.
This product contains natural ingredients; color variations may occur.
Oligonol® is a registered trademark of the Amino Up Chemical Company, Sapporo, Japan.
Science and Quality
Berberine+ GlucoGold—A Clinically Studied Formula for Blood Sugar Health
A double-blind, randomized, placebo-controlled clinical study evaluated the effects of Berberine+ GlucoGold in the recommended dosage of one tablet three times daily or placebo in 112 individuals over 12 weeks. Research showed that Berberine+GlucoGold helps maintain blood sugar levels already in the normal range and supports the normal response of insulin to blood sugar, normal insulin sensitivity, and healthy levels of total and LDL cholesterol. Plus, individuals showed an 88.6% improvement in DIO (oral Disposition Index—a measure of pancreatic beta-cell function).
Berberine Helps Maintain Blood Sugar Levels in the Normal Range
In one part of a two-part study, individuals were given three 500 mg doses of berberine daily (the same dose in Berberine+ GlucoGold) for three months. It showed that berberine helps maintain blood glucose levels already in the normal range and supports healthy lipid profiles.1 Plus, a second randomized, double-blind, placebo-controlled clinical study (where individuals also took three 500 mg doses of berberine daily) confirmed that berberine helps maintain blood sugar levels already in the normal range.2
A third study further shows the effectiveness of berberine. In this three month, double-blind, placebo-controlled study, individuals were given 1,000 mg of berberine daily or a placebo. The individuals who took berberine noticed that it helped maintain blood glucose levels already in the normal range and supported healthy lipid profiles.3
Based on this fantastic research, Dr. Whitaker included BerberPure™ berberine in his advanced supplement for blood sugar support, Berberine+ GlucoGold. Chosen for it's exceptional quality, BerberPure is sourced globally and manufactured and triple-tested in the USA.
Crominex 3+ Promotes Healthy Blood Glucose and Total Cholesterol Levels
In a 12-week, randomized, double-blind, placebo-controlled study, individuals were divided into three groups and given either 400 mcg or 200 mcg of Crominex 3+ or a placebo. The 400 mcg dose of Crominex 3+—the same amount in Berberine+GlucoGold—was shown to be more effective than 200 mcg or the placebo in promoting blood glucose levels already in the normal range. The research also suggests it supports healthy total and LDL cholesterol levels, while promoting a healthy inflammatory response and supporting healthy endothelial function (the health of the cells lining your blood vessels).4
What’s better, a second randomized, double-blind, placebo-controlled study was done on Crominex 3+ with equally compelling results. In this 12-week study, 400 mcg and 200 mcg per day of Crominex 3+ was again tested against a placebo. And again, the 400 mcg dose was found to help maintain normal blood glucose levels, support healthy total and LDL cholesterol levels, promote a healthy inflammatory response, and healthy endothelial function.5
Cinnamon Supports Blood Sugar Health
In a double-blind, placebo-controlled study examining the effects of 1g cinnamon daily (the equivalent dosage in Berberine+ GlucoGold), it was shown to help maintain blood glucose levels already in the normal range and support healthy lipid profiles.6
Why Oligonol Is So Effective
Oligonol, which has been consumed since ancient times in China and southern Southeast Asia, is derived from the lychee fruit and green tea. It’s rich in proanthocyanidins (PACs), a type of polyphenol that has shown high antioxidant activity in vitro. However, their absorption in the body is low when administered orally.1 Scientists were able to solve this problem using a patented process to break down large PAC molecules into smaller compounds (monomers, dimers, and trimers). They developed a low-molecular-weight polyphenol called “Oligonol”. Oligonol’s unique, small polyphenols have improved bioavailability over non-processed lychee extracts.1 In addition, tests show that Oligonol contains substantially more of the easily absorbed PACs (40% by weight) than those found in generic lychee, pine bark or grape seed extracts (10-20% by weight). It is known that when vascular endothelial cells are damaged due to hyperglycemia and oxidative stress, the production of nitric oxide (NO) decreases reduced microcirculation. In vitro studies showed Oligonol supports vascular endothelial cells, and NO synthesis.7
1 Yin J, et al. Metab. 2008;57(5):712–7.
2 Pérez-Rubio K G, et al. Metab Syndr Relat Disord. 2013;11,366–9.
3 Zhang Y, et al. J Clin Endocrinol Metab. 2008;93,2559–65.
4 Usharani P, et al. Natreon Inc. Unpubl. 2013
5 Usharani P, et al. Natreon Inc. Unpubl. 2014
6 Khan A, et al. Diabetes Care. 2003;26(12):3215–8.
7Bagchi D, et al. CRC Press/Taylor & Francis Group, LLC. Boca Raton, FL. 2010;91-101.
Berberine+ GlucoGold is manufactured under stringent quality controls:
- Manufactured to exacting standards using highest quality raw materials
- Produced in accordance with our strict Standard Operating Procedures (SOPs) that meet those set by the FDA’s Good Manufacturing Practices
- Every batch tested to verify purity and potency specifications are met
- Quality assured with our Triple Testing Philosophy™
- Backed by our 100% satisfaction guarantee
Product reviews and ratings are provided for informational purposes only and reflect solely the views and opinions expressed by the individual contributors and not those of Healthy Directions LLC. Healthy Directions LLC neither verifies nor endorses any claims made in these reviews and ratings.