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MK-7

Vitamin K2 supplement supports optimal calcium absorption

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MK-7 helps shuttle calcium out of your bloodstream and into your bones

Calcium is extremely important for your bones, but presents a little-known yet serious impact on your heart health by collecting on blood vessel walls. If you’re taking calcium supplements, MK-7 is a must!

The good news is a special, highly absorbable form of vitamin K2 called MK-7 helps move the calcium from your bloodstream and shuttle it to your bones, where it’s needed to build strength and durability. And with Healthy Directions’ MK-7, you’re getting the full recommended dose (180 mcg) of K2.

Formulated with the most bioavailable and effective form of K2

If your multivitamin includes vitamin K, it's K1, NOT K2. And even if it is K2, it's highly unlikely that it's the MK-7 form of K2—the most bioavailable and beneficial form for your cardiovascular system and your bones. While K1 is found commonly in leafy vegetables and plays a role in normal blood clotting, only 10% of the vitamin K1 in these foods is absorbed by your body. In addition, K1 does not stay in your body anywhere near as long as K2. And it's only K2 that's been studied for effectively helping to keep calcium out of your blood and blood vessels.

A full recommended dose for optimal absorption

There are a lot of K2 products available that contain less than 180 mcg of MK-7. Instead, many of these supplements use blends that are actually predominantly MK-4, the cheaper, far less active relative of MK-7. The Healthy Directions MK-7 formula gives you the full recommended dose (180 mcg) of the most effective form of vitamin K2 you need every day to support bone and cardiovascular health.

Ingredients and Dosage

Doctor's Suggested Use: ï»¿Take 1 softgel daily.

Serving Size: 1 Softgel
Servings Per Container: ï»¿30

Ingredient Amount Per Serving % DV
Menaquinone-7 (Vitamin K2) (MenaQ7 ®) 180 mcg *
* Daily Value (DV) not established.

Other ingredients: Medium chain triglycerides, gelatin, glycerin, olive oil, purified water

Precautions: Consult a health care practitioner before use if you take warfarin or other blood thinning products, or are pregnant or nursing, have a serious medical condition, or use any medications.

Keep out of reach of children.


  • Gluten Free

MenaQ7 ® is a registered trademark of NattoPharma ASA, Norway; Patented in the United States and Canada. US Patent Numbers 8,728,553 & 8,354,129; Canada Patent Number 2,347,387

Science and Quality

Vitamin K functions in the body to modify certain proteins that ensure proper calcium utilization in the bones and cardiovascular system.

Vitamin K2 is more bioavailable than K1 and has a longer half-life (how long it remains in the bloodstream), which allows for a greater tissue distribution than vitamin K1. Because of these factors, vitamin K2 is better at promoting a healthy cardiovascular system by optimizing calcium utilization, which in turn keeps calcium in the bones and out of the arteries.


Product Quality

  • Each ingredient's potency is verified. View the Certificate of Analysis.
  • Manufactured to exacting standards using highest quality raw materials
  • Produced in accordance with our strict Standard Operating Procedures (SOPs) that meet those set by the FDA’s Good Manufacturing Practices
  • Every batch tested to verify purity and potency specifications are met
  • Quality assured with our Triple-Testing Philosophyâ„¢
  • Backed by our 100% satisfaction guarantee

What is MK-7 and how is it different from vitamin K?

MK-7 is a form of vitamin K2 that helps activate proteins responsible for directing calcium into bones where it's needed most. Unlike vitamin K1, which primarily supports normal blood clotting, MK-7 provides lasting support for healthy bones and efficient calcium utilization throughout the body.
Read More
MK-7 (menaquinone-7) is one of the most researched forms of vitamin K2. While vitamin K1 is mainly involved in supporting normal blood clotting, vitamin K2—especially MK-7—plays a unique role in bone health by activating proteins that help bind calcium into bone tissue.

Healthy Directions Clinical Grade MK-7 features MenaQ7®, a patented form of vitamin K2. Each softgel provides 180 mcg, the same amount used in published clinical research evaluating bone mineral density, bone mineral content, and bone strength in postmenopausal women. Because MK-7 remains active in the body longer than other forms of vitamin K, it provides sustained support with just one daily softgel.

What are the benefits of MK-7 for bone health?

MK-7 supports bone health by helping activate proteins that bind calcium into bone tissue. Clinical research on MenaQ7® has shown support for healthy bone mineral density, bone mineral content, bone strength, and normal bone building, especially in aging adults.
Read More
Healthy bones depend on more than calcium alone—they also require nutrients that help the body properly use calcium. MK-7 activates osteocalcin, a protein that binds calcium into the bone matrix where it contributes to strength and structure.

Healthy Directions Clinical Grade MK-7 contains MenaQ7®, a patented key ingredient used in research in postmenopausal women receiving 180 mcg daily. In clinical research, participants taking MenaQ7® experienced improvements in markers of bone health, including bone mineral density, bone mineral content, bone strength, and healthy bone-building activity compared with placebo. These findings suggest that consistent daily intake of MK-7 can help support healthy bones as part of an overall bone health routine.

How does MK-7 help your body use calcium?

MK-7 helps activate specialized proteins that direct calcium into bones instead of leaving it circulating unused. This process supports healthy calcium utilization and helps maintain strong, healthy bones when combined with adequate calcium and vitamin D intake.
Read More
Calcium is essential for healthy bones, but your body also needs nutrients that help put calcium where it's most beneficial. MK-7 activates osteocalcin, a protein responsible for binding calcium into the bone matrix. Without enough activated osteocalcin, calcium cannot be incorporated into bone tissue as efficiently.

Healthy Directions Clinical Grade MK-7 delivers 180 mcg of MenaQ7®, which has been researched for its effects on healthy calcium utilization and bone health. Research demonstrated improvements in biomarkers related to osteocalcin activation, along with positive changes in bone mineral density and bone mineral content. By supporting optimal calcium utilization, MK-7 helps maximize the benefits of calcium consumed through diet or supplements.

What makes MenaQ7® different from other forms of vitamin K2?

MenaQ7® is a patented form of MK-7 vitamin K2. It has been researched in human clinical trials evaluating bone mineral density, bone strength, and calcium utilization, making it one of the most scientifically supported forms of vitamin K2 available.
Read More
Not all vitamin K2 supplements are the same. Healthy Directions Clinical Grade MK-7 uses MenaQ7®, a premium patented form of MK-7 that has been extensively studied in published human clinical trials.

The clinical research supporting MenaQ7® evaluated 180 mcg daily, the same dosage provided in Healthy Directions Clinical Grade MK-7. In these studies, researchers observed improvements in osteocalcin activation, bone mineral density, bone mineral content, bone strength, and other measures associated with healthy bone maintenance in postmenopausal women. Choosing a clinically backed branded key ingredient like MenaQ7® provides added confidence that the dosage and ingredient have been evaluated for efficacy and quality.

Why does Healthy Directions use 180 mcg of MK-7?

Healthy Directions provides 180 mcg of MenaQ7® MK-7 because this is the dosage used in published clinical research demonstrating support for bone mineral density, bone strength, and healthy calcium utilization in postmenopausal women.
Read More
The amount of an ingredient matters just as much as the ingredient itself. Healthy Directions Clinical Grade MK-7 supplies 180 mcg of MenaQ7®, matching the dosage used in a landmark clinical study involving 223 healthy postmenopausal women.

Researchers found that participants taking 180 mcg daily experienced significant improvements in markers associated with bone health, including activated osteocalcin, bone mineral density, bone mineral content, bone strength, and measures related to healthy vertebral structure compared with placebo. By providing the clinical amount of MenaQ7®, Healthy Directions allows customers to use the same dosage evaluated in human research, rather than relying on lower, untested amounts.

Can MK-7 help maintain bone density?

Yes. Clinical research on MenaQ7® has shown that daily supplementation with 180 mcg of MK-7 supports healthy bone mineral density and bone mineral content, particularly in postmenopausal women. By helping activate bone-building proteins, MK-7 supports the body's natural process of maintaining strong, healthy bones over time.
Read More
Bone density naturally declines with age, making nutritional support increasingly important. MK-7 helps activate osteocalcin, a vitamin K-dependent protein that binds calcium into the bone matrix where it contributes to bone strength and structure.

Healthy Directions Clinical Grade MK-7 contains 180 mcg of MenaQ7®, the same dosage evaluated in a published three-year clinical trial involving healthy postmenopausal women. Researchers observed significant improvements in biomarkers of bone health along with support for healthy bone mineral density and bone mineral content compared with placebo. These findings suggest that consistent daily supplementation with MK-7 can help maintain healthy bones as part of a comprehensive bone health program that includes adequate calcium, vitamin D, exercise, and a balanced diet.

Does MK-7 support bone strength as you age?

Yes. Healthy aging is associated with gradual changes in bone strength. Clinical research shows that MenaQ7® supports healthy bone-building activity and measures associated with bone strength, helping maintain skeletal health as part of an overall healthy lifestyle.
Read More
Strong bones depend on more than bone density alone—they also require healthy bone quality and normal bone remodeling. MK-7 activates proteins involved in building and maintaining bone structure, helping support these natural processes throughout adulthood.

The clinical study behind MenaQ7® demonstrated improvements in several measures associated with bone strength, including an impact strength index and markers of healthy bone-building activity. Researchers also observed support for maintaining vertebral structure over time in healthy postmenopausal women taking 180 mcg daily. These findings highlight the importance of vitamin K2 in maintaining skeletal integrity as we age. Healthy Directions Clinical Grade MK-7 delivers the same clinical dosage used in this research.

How long does it take for MK-7 to work?

MK-7 begins supporting calcium-regulating proteins soon after supplementation, but measurable changes in bone health occur gradually. Clinical studies of MenaQ7® observed improvements in certain bone-related measures beginning around 12 months, with additional benefits seen after longer-term daily use.
Read More
Bone remodeling is a slow, continuous process, so nutritional interventions typically require consistent use over time. While MK-7 starts activating vitamin K-dependent proteins soon after it is absorbed, improvements in bone mineral density and other structural measures develop gradually.

The landmark clinical study evaluating 180 mcg of MenaQ7® daily reported changes in osteocalcin activation earlier in supplementation, with improvements in bone mineral content, bone mineral density, and measures associated with bone strength becoming evident during follow-up, including findings at 12 months and 24 months. For best results, Healthy Directions recommends taking one softgel daily as part of a consistent bone health routine.

Can I take MK-7 with vitamin D3?

Yes. Vitamin D3 and MK-7 have complementary roles in bone health. Vitamin D3 is required for normal calcium absorption, while MK-7 helps activate proteins that direct calcium into bones. Many healthcare professionals recommend using them together as part of a comprehensive bone health regimen.
Read More
Vitamin D3 and MK-7 work at different stages of calcium utilization. Vitamin D is required for normal calcium absorption and to prevent high serum parathyroid hormone (PTH) levels, which can mobilize calcium from bone and reduce bone mass.

Because these nutrients perform complementary functions, they are often used together to support healthy bones. Healthy Directions Clinical Grade MK-7 provides 180 mcg of MenaQ7®, which supports healthy calcium utilization and bone-building processes. Although vitamin D3 is not included in this formula, many individuals choose to pair MK-7 with vitamin D3 and adequate dietary calcium as part of a comprehensive bone health strategy. As always, consult your healthcare provider about the supplements that are appropriate for your individual needs.

Who should consider taking MK-7?

MK-7 may be beneficial for adults who want to support healthy bones, especially as they age. It can be particularly helpful for postmenopausal women and individuals seeking additional nutritional support for healthy calcium utilization and bone mineral density. People taking blood-thinning medications should consult their healthcare provider before using vitamin K supplements.
Read More
Healthy bone maintenance becomes increasingly important with age, making vitamin K2 an important nutrient for many adults. Clinical research on MenaQ7® has focused primarily on healthy postmenopausal women, where supplementation with 180 mcg daily supported healthy bone mineral density, bone mineral content, and bone strength.

Adults looking to optimize calcium utilization, complement calcium and vitamin D intake, or support skeletal health may also consider MK-7 supplementation. However, because vitamin K can interact with certain anticoagulant medications such as warfarin, anyone taking blood thinners or managing a medical condition should consult their healthcare provider before beginning supplementation. Healthy Directions recommends taking one softgel daily unless otherwise directed by a healthcare professional.

Is MK-7 especially beneficial for postmenopausal women?

Yes. One of the largest clinical studies on MenaQ7® evaluated healthy postmenopausal women and found that daily supplementation with 180 mcg supported healthy bone mineral density, bone mineral content, bone strength, and bone-building activity over time.
Read More
After menopause, declining estrogen levels can accelerate natural bone loss, making nutritional support increasingly important. Vitamin K2, particularly in the form of MK-7, plays an important role by activating osteocalcin—a protein that helps bind calcium into bone tissue.

Healthy Directions Clinical Grade MK-7 provides 180 mcg of MenaQ7®, matching the dosage used in a landmark clinical study involving 223 healthy postmenopausal women. Researchers reported improvements in activated osteocalcin along with support for healthy bone mineral density, bone mineral content, and measures associated with bone strength. These findings make MK-7 an excellent nutritional choice for women looking to support healthy bones during and after menopause as part of a comprehensive wellness plan that includes calcium, vitamin D, regular exercise, and a balanced diet.

Does MK-7 support heart health?

Vitamin K2 has been studied for its role in calcium metabolism throughout the body. However, Healthy Directions Clinical Grade MK-7 is specifically formulated and marketed to support healthy bones and calcium utilization. The product's supported benefits focus on bone health rather than cardiovascular outcomes.
Read More
Vitamin K2 has attracted scientific interest because it activates proteins involved in calcium utilization. While researchers continue to investigate how vitamin K2 may influence cardiovascular health, Healthy Directions Clinical Grade MK-7 is supported by clinical evidence specifically related to bone health.

The MenaQ7® clinical research highlighted in the product documentation evaluated outcomes such as healthy bone mineral density, bone mineral content, osteocalcin activation, bone strength, and healthy bone-building activity—not cardiovascular endpoints. For that reason, Healthy Directions appropriately focuses product messaging on helping support healthy bones and supporting optimal calcium utilization. Consumers looking for cardiovascular support should choose products specifically formulated and clinically supported for heart health.

What's the difference between vitamin K1 and vitamin K2?

Vitamin K1 primarily supports normal blood clotting, while vitamin K2 helps activate proteins involved in healthy calcium utilization. MK-7 is a bioavailable form of vitamin K2 that provides lasting support for bone health and calcium utilization.
Read More
Although both vitamins belong to the vitamin K family, they perform different roles in the body. Vitamin K1 (phylloquinone), found primarily in leafy green vegetables, is best known for supporting normal blood clotting.

Vitamin K2 (menaquinone), especially the MK-7 form, supports healthy bones by activating osteocalcin and other vitamin K-dependent proteins involved in calcium utilization. MK-7 also has a longer half-life than many other forms of vitamin K, allowing it to remain available in the body for extended periods after supplementation. Healthy Directions Clinical Grade MK-7 uses MenaQ7®, a clinically backed source of MK-7 that has demonstrated support for healthy bone mineral density, bone strength, and bone-building activity.

Can I get enough MK-7 from food?

MK-7 occurs in only a limited number of foods, particularly fermented soybeans (natto). Because these foods are not commonly consumed in many Western diets, some people choose an MK-7 supplement to help ensure consistent daily intake.
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Unlike vitamin K1, which is abundant in leafy green vegetables, MK-7 is found in relatively few foods. The richest dietary source is natto, a traditional fermented soybean food commonly eaten in Japan. Smaller amounts may also be present in certain fermented cheeses and other fermented foods.

Because many people rarely consume natto or other foods rich in MK-7, daily intake can vary considerably. Healthy Directions Clinical Grade MK-7 provides a consistent 180 mcg of MenaQ7® in a convenient once-daily softgel. Supplementation offers an easy way to obtain the same amount of MK-7 that has been evaluated in human clinical research supporting healthy bone mineral density and calcium utilization.

Why is MK-7 considered the preferred form of vitamin K2?

MK-7 is considered the preferred form of vitamin K2 because it remains active in the body longer than many other forms of vitamin K, allowing for sustained support with once-daily supplementation. It is also one of the most extensively researched forms of vitamin K2.
Read More
Several forms of vitamin K2 exist, but MK-7 has become the preferred choice for supplementation because of its excellent bioavailability and long-lasting activity in the body. These characteristics allow once-daily supplementation to provide ongoing support for vitamin K-dependent proteins involved in bone health.

Healthy Directions Clinical Grade MK-7 uses MenaQ7®, a patented source of natural MK-7 that has been evaluated in published human clinical studies. Research using 180 mcg daily demonstrated support for osteocalcin activation, healthy bone mineral density, bone mineral content, bone strength, and healthy bone-building activity. Combined with its long duration of action, this extensive body of clinical research makes MK-7 one of the most trusted and scientifically supported forms of vitamin K2 available today.

Can MK-7 help direct calcium to your bones?

Yes. MK-7 activates osteocalcin, a vitamin K-dependent protein that helps bind calcium into bone tissue. This supports healthy calcium utilization by helping your body use the calcium you consume where it's needed most—for maintaining healthy bones.
Read More
Calcium is essential for strong bones, but simply consuming calcium isn't enough. Your body also needs nutrients that help activate the proteins responsible for incorporating calcium into the bone matrix. That's where MK-7 plays an important role.

Healthy Directions Clinical Grade MK-7 contains 180 mcg of MenaQ7®, a researched form of vitamin K2 that activates osteocalcin. In human clinical research, MenaQ7® improved markers of activated osteocalcin along with supporting healthy bone mineral density, bone mineral content, and bone-building activity. By supporting your body's natural calcium utilization process, MK-7 helps ensure the calcium you consume can contribute to healthy bone maintenance as part of an overall bone health program.

Is MK-7 safe to take every day?

For most healthy adults, yes. Healthy Directions Clinical Grade MK-7 is designed for daily use, with one softgel providing 180 mcg of MenaQ7®. People taking blood-thinning medications or managing certain medical conditions should consult their healthcare provider before taking vitamin K supplements.
Read More
Healthy Directions recommends taking one softgel daily, providing 180 mcg of MenaQ7® MK-7—the same amount used in published clinical research supporting bone health. Daily supplementation helps maintain consistent levels of vitamin K2 to support ongoing activation of bone-building proteins.

Vitamin K2 is generally well tolerated when used as directed. However, because vitamin K can affect how certain anticoagulant medications (such as warfarin) work, individuals taking blood-thinning medications should consult their healthcare provider before starting MK-7. Likewise, anyone who is pregnant, nursing, has a medical condition, or takes prescription medications should discuss supplementation with their healthcare professional to determine whether MK-7 is appropriate for their individual health needs.

Can I take MK-7 with calcium supplements?

Yes. MK-7 and calcium have complementary roles in bone health. Calcium provides the building blocks for bone, while MK-7 helps activate proteins that support healthy calcium utilization. Many people take them together as part of a comprehensive bone health regimen.
Read More
Calcium is an important mineral for maintaining healthy bones, but it works best when combined with nutrients that help the body use it effectively. MK-7 activates osteocalcin, which helps bind calcium into bone tissue during the natural bone remodeling process.

For this reason, many healthcare professionals recommend combining adequate calcium intake with vitamin D3 and vitamin K2 as part of a well-rounded bone health plan. Healthy Directions Clinical Grade MK-7 delivers 180 mcg of MenaQ7® to support healthy calcium utilization and bone-building activity. If you currently take calcium supplements or are considering adding one, speak with your healthcare provider about the combination that's right for your individual nutritional needs.

Who should not take MK-7?

People taking vitamin K-antagonist blood-thinning medications, such as warfarin, should consult their healthcare provider before taking MK-7. Anyone who is pregnant, nursing, has a medical condition, or takes prescription medications should also seek medical advice before starting supplementation.
Read More
Although MK-7 is appropriate for many healthy adults, it may not be suitable for everyone. Because vitamin K plays a role in normal blood clotting, supplements containing vitamin K2 can interact with anticoagulant medications that work by blocking vitamin K activity, including warfarin.

If you're taking prescription blood thinners, have a bleeding disorder, are preparing for surgery, or have another medical condition requiring medication management, consult your healthcare provider before taking MK-7. Pregnant or nursing women should also seek professional guidance before using any dietary supplement. Following these precautions helps ensure that MK-7 supplementation fits safely within your overall healthcare plan while allowing your provider to monitor any necessary medication adjustments.

Why choose Healthy Directions Clinical Grade MK-7?

Healthy Directions Clinical Grade MK-7 delivers 180 mcg of patented MenaQ7®, the same dosage used in published clinical research supporting bone mineral density, bone strength, healthy bone-building activity, and calcium utilization. One convenient softgel provides clinically backed nutritional support for lasting bone health.
Read More
Not all vitamin K2 supplements provide the same ingredient quality or clinically researched dosage. Healthy Directions Clinical Grade MK-7 contains MenaQ7®, one of the world's most extensively studied forms of MK-7 vitamin K2.

Each once-daily softgel provides 180 mcg, matching the dosage evaluated in a landmark clinical study involving healthy postmenopausal women. The research demonstrated support for healthy bone mineral density, bone mineral content, bone strength, healthy bone-building activity, and activation of osteocalcin—a key protein involved in calcium utilization. By combining a premium branded ingredient with the clinical amount, Healthy Directions Clinical Grade MK-7 offers science-backed nutritional support for maintaining healthy bones as part of an overall wellness routine.

Product reviews and ratings are provided for informational purposes only and reflect solely the views and opinions expressed by the individual contributors and not those of Healthy Directions LLC. Healthy Directions LLC neither verifies nor endorses any claims made in these reviews and ratings.