Item #IP201

Dr. Joseph Pergolizzi

Instaflex Pain Relief Cream

Doctor developed, clinically studied pain relief from arthritis, back pain, strains and joint and muscle pain

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Relieve Your Toughest Pain in Minutes—Lasts for Hours!

Unlike many pain creams, Instaflex® Pain Relief Cream is doctor developed, clinically studied, and is formulated with an exclusive oxygenated oil, that works quickly to:

  • Deliver nearly TWICE the pain relief *
  • Provide fast relief from arthritis, back pain, strains and joint and muscle pain
  • Penetrate deeply into the skin in minutes with no lingering medicinal smell

Clinical study shows nearly TWICE the relief

A randomized, double-blind, controlled comparison study found that Instaflex Pain Relief Cream was nearly 2X as effective at relieving pain as a comparable menthol-only rub. Adult subjects using Instaflex reported improvements in pain, mobility, and soreness.

Ancient discovery, modern clinical results

In Biblical times, stories abounded of a mysterious oil used by ancient healers. It was said to be a precious and wonderfully soothing elixir. Traditionally, this healing oil was made by leaving an essential oil in an open vat for 20 years, allowing the sun's rays to infuse the oil with oxygen.

Today, modern science has rediscovered the power of hyper-oxygenated oil, and the oxygenation process has been shortened to just three days. Athletes in Europe have been using this oil for years, but it took leading pain expert Dr. Joseph Pergolizzi to bring it home to the U.S. and combine it with soothing menthol to create the formula for Instaflex Pain Relief Cream.

Meet Dr. Joseph Pergolizzi

Instaflex Pain Relief Cream was formulated by internationally recognized Dr. Joseph Pergolizzi, an actively practicing physician, and highly sought-after pain relief instructor, treating patients in his advanced Florida practice. Just some of the highlights of his career include…

  • Author of over 200 peer-reviewed articles, abstracts, platform presentations, and book chapters in his areas of expertise
  • Recipient of Top Anesthesiologist & Pain Management Physician for 2018 in Naples, Florida
  • Recipient of American Health Council’s 2017 Best in Medicine Award
  • Named "One of America's Most Compassionate Doctors" and winner of the 2012 Patient’s Choice Award


*Instaflex Pain Relief Cream has been clinically shown to relieve pain nearly twice as well as a comparable menthol-only cream (1.25% concentration). Taylor R. et al. Pain Practice 2012;12(8):610-19.

Ingredients and Dosage

Uses: temporarily relieves minor aches and pains of muscles and joints associated with simple backaches, arthritis, strains, sprains, bruises

Directions: Adults and children 12 years of age and older. Apply to affected area no more than 3–4 times daily. Children under 12 years of age, consult a doctor.

IngredientPurpose
Menthol (1.25%)Topical Analgesic

Inactive ingredients: C13-14 Isoparaffin, Citrus Aurantium Dulcis (Orange) Oil, Ethylhexylglycerin, Eucalyptus Globulus Oil, Glyceryl Stearate, Laureth-7, Oxygenated Corn Oil, PEG-100 Stearate, Phenoxyethanol, Polyacrylamide, Polysorbate-20, Water

Warning: For external use only. Use only as directed.

Do not use with a heating pad, it may blister skin; on open wounds or damaged skin

When using this product avoid contact with eyes; do not bandage tightly

Ask a doctor before use if you have redness over the affected area

Stop use and consult a doctor if: skin redness or excessive skin irritation develops; condition worsens or symptoms persist for more than 7 days; symptoms clear up and occur again in a few days

Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

Other information: Keep product at room temperature and humidity [59–86°F (15–30°C), 40% RH]. Do not freeze. For Lot Number and Expiration Date, see crimp at end of tube.

  • Dermatologist Tested
    Dermatologist Tested

Science and Quality

A High-Quality Source for Pain Relief

Instaflex Pain Relief Cream harnesses the soothing power of menthol (a proven OTC pain reliever) in combination with a ”hyper-oxygenated oil" for fast-acting, long-lasting pain relief. This exclusive formula provides joints and muscles with relief from aches and strains and even the pain of arthritis.

In a double-blind, randomized, controlled head-to-head study, Instaflex Pain Relief Cream was tested against a comparable, menthol-only pain cream. By the end of the week-long treatment, acute pain in Instaflex users had decreased by nearly double that of those using the menthol-only cream. In addition, subjects using Instaflex showed a significantly greater improvement in mobility compared to those using the menthol-only cream.1 

Essential oils and ancient practices:

How oil, oxygen and sunshine soothe skin

In the 1950s and '60s, Professor Pierre Baranger—a member of the Pasteur Institute's scientific team—traveled throughout India studying the healing powers of oils. These oils were known throughout the East for their exceptional restorative virtues.

Upon further study into the healing qualities of oils, Baranger became perplexed as to why modern doctors in the mainland cities weren't using the oils. Local healers informed him that it was because modern doctors didn't know the secret to properly preparing the oils. To truly harness its natural powers, the oil first had to be exposed to sun and open air for 20 years. Using all he had learned from the medicine men of India, Baranger was able to pioneer a process that replicates 20 years of oxygenation in just three days. This allowed him to introduce these powerful soothing oils to the West.

Dr. Pergolizzi was first introduced to the benefits of oxygenated oil while traveling through Germany. This inspired Dr. Pergolizzi to learn more about oxygenated oil, the history of its use, and how he could best incorporate it into his own pain-relief treatments.

Dr. Pergolizzi's Instaflex Pain Relief Cream utilizes the features of oil unlocking a world of potential for both soothing and moisturizing skin.


1 Taylor R, et al. Pain Practice. 2012;12(8):610–19. Click here for full study.

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