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Item #CRD01

Dr. Stephen Sinatra

CardioSense Probiotic

3-in-1 next-generation probiotic for better digestive, heart, and immune health!

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3-in-1 next generation

probiotic for digestive, heart, and immune support

Digestive Support

Heart Support

Immune Support

Cardiologist Formulated

CardioSense Probiotic
Clinically Validated TriBiotic Probiotic Blend

Clinically Validated TriBiotic Probiotic Blend

This innovative probiotic delivers 12 billion CFU of robust benefits in a unique TriBiotic Probiotic Blend plus three Bifidobacteria strains to deliver clinically validated digestive, heart, and immune benefits.

Each dose delivers all this using stay-fresh innovative technology to keep you feeling your best. And you won’t find this probiotic combination anywhere else!

Comprehensive Digestive Support

Comprehensive Digestive Support

The Floradapt Intensive GI strain was shown in a clinical study to be hardy against the acidic environment of the stomach and intestines and was shown in multiple studies to support the digestive system and digestive comfort.*,** You also get a Bifido blend of 3 strains that provide support for your lower intestine, giving you complete digestive support.

*Lorenzo-Zuniga V, et al. World J Gastroenterol. 2014 Jul 14;20(26):8709–16.
**Barraza-Ortiz DA, et al. Dig Dis. 2021;39(3):294–300.

HUGE heart benefits

HUGE heart benefits

The Floradapt Cardio blend delivers a combination of three Lactobacillus plantarum strains that have been clinically validated to provide excellent support for overall heart support benefiting total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides and lipid oxidation.*,**

*Fuentes M, et al. Br J Nutr. 2012 May 28;109(10):1866–72.
**Fuentes M, et al. Mediterranean J of Nutr & Metabolism. 2016;9(2):125–35.

Robust immune support!

Robust immune support!

Since so much of your digestive system lives in your gut, Dr. Sinatra included robust Floradapt Mature Immune Defense, which was specifically studied in older adults and found to support the adaptive immune system—the part of our immune response that changes the most as we age. It also supports immune function and immune system cells.*

*Mane J, et al. Nutr Hosp. 2011;26(1):228–35.

Innovative bottle technology for moisture protection and enhanced stability

CardioSense Probiotic is bottled with technology that helps protect the probiotic from moisture. This ultimately helps provide enhanced stability and ensures efficacy. And, helps deliver a long shelf life of 24 months. Plus, no refrigeration is necessary!

Vegetarian capsules release the probiotics exactly when and where you need them

CardioSense Probiotic was made using innovative Capsugel Vcaps Plus Capsules that are vegetarian and dissolve quickly using immediate-release technology. They also feature a lower moisture content and sensitivity, making them less brittle and less likely to break.

statin deplete CoQ10

Floradapt Intensive GI + Bifido Blend

Remarkable digestive support starts with Floradapt Intensive GI. In one clinical study, 38% of participants experienced improvement in abdominal discomfort and over 44% experienced improvement in stool consistency.*,** Benefits included improved regularity, better stool consistency, and digestive comfort support. Plus, it was shown to reduce occasional diarrhea, control occasional gas and flatulence, and support abdominal calm in those with GI concerns after lactose intake.***

*Lorenzo-Zuniga V, et al. World J Gastroenterol. 2014 Jul 14;20(26):8709–16.
**Barraza-Ortiz DA, et al. Dig Dis. 2021;39(3):294–300.
***Cano-Contreras A.D, et al. J Clin Gasteroenterol. 2020;0(0):1 -7.

Heart Blend Floradapt Cardio

Heart Blend Floradapt Cardio

The Floradapt Cardio blend features a combination of three Lactobacillus plantarum strains that have been clinically validated*,** to provide excellent lipid metabolism and overall heart support, to help benefit levels of total cholesterol and LDL cholesterol, triglycerides, lipid oxidation, and levels of HDL cholesterol.

*Fuentes M, et al. Br J Nutr. 2012 May 28;109(10):1866–72.
**Fuentes M, et al. Mediterranean J of Nutr & Metabolism. 2016;9(2):125–35.

Ashwagandha helps you cope with stress

Impressive immune benefits

The unique dual-strain blend Floradapt Mature Immune Defense strain was specifically studied in an older population and found to support and benefit immune response and immune function, levels of immune system cells, and levels of IgA, a key immune factor in supporting mucous membranes.* In addition, this strain also supports C-Reactive Protein**,***, a critical marker of how your body responds to inflammation.

*Mane J, et al. Nutr Hosp. 2011;26(1):228 -35.
**Bosch M, et al. Nutr Hosp. 2012;27(2):504–9.
***Bosch Gallego M, et al. Nutr Hosp. 2011;26(3):642–45.

Formulated by Integrative Cardiologist Stephen Sinatra, M.D.

A true pioneer, Dr. Sinatra spent more than 40 years in clinical practice, including serving as an attending physician and chief of cardiology at Manchester Memorial Hospital, then going on to formulate his advanced line of heart health supplements. His integrative approach to heart health has changed the lives of hundreds of thousands.

Ingredients and Dosage

Doctor's Suggested Use: Take 1 vegetarian capsule daily.

Serving Size: 1 Vegetarian Capsule

Servings Per Container: 30

Ingredient Amount Per Serving % DV
TriBiotic Probiotic Blend (264 mg) 12 Bil. CFU *
Digestive Probiotics Floradapt™ Intensive GI
(P. acidilactici KABP™-021, L. plantarum
KABP™-022, L. plantarum KABP™-023)
8.8 Bil. CFU *
  Bifido Blend (B. bifidum, B. lactis, B. longum) 1.5 Bil. CFU *
Cardio Probiotics Floradapt™ Cardio
(L. plantarum KABP™-011, L. plantarum
KABP™-012, L. plantarum KABP™-013)
1.2 Bil. CFU *
Immune Probiotics Floradapt™ Mature
Immune Defense (L. plantarum KABP™-031,
L. plantarum KABP™-032)
500 Mil. CFU *

Other ingredients: Microcrystalline cellulose, hypromellose

Precautions: Consult a health care practitioner if you are pregnant or nursing, have a serious medical condition, or use any medications.

Keep out of reach of children.


  • Gluten Free

  • Soy Free

Floradapt™ and KABP™ are trademarks of Kaneka Corporation.

Science and Quality

Floradapt™ Intensive GI

In a randomized, double-blind, placebo-controlled study, Floradapt Intensive GI was shown to: 1

  • Support overall digestive health
  • Support digestive comfort
  • Improve digestive quality of life
  • Support mental quality of life in those with digestive concerns
  • Improve gut-related anxiousness and discomfort

An unpublished randomized, single-blinded, placebo-controlled study demonstrated that Floradapt Intensive GI:

  • Supports healthy stool consistency2
  • Improves digestive quality of life
  • Supports overall digestive health

A randomized, single-blind, placebo-controlled study evaluating the effects of Floradapt Intensive GI on subjects sensitive to lactose showed that Floradapt Intensive GI helps: 3

  • Reduce occasional diarrhea in those with GI concerns after lactose intake
  • Enhance abdominal comfort in those with GI concerns after lactose intake
  • Gas and flatulence in those with GI concerns after lactose intake
  • Support abdominal calmness in those with GI concerns after lactose intake

Bifido Blend

  1. B. bifidum: Considered to be amongst the first species to colonize in the human gastrointestinal tract and also serve an integral role in maintaining gut homeostasis. They are key members of the human gut microbiota especially during the first few years following birth.
  2. B. lactis: This is another type of bacteria commonly found in the large intestine. This species is present in many foods, especially dairy products. It also has high survival rate in acidic environments in addition to a high bile tolerance. Therefore, B. lactis has well-established probiotic characteristics that may be of benefit to human health.
  3. B. longum: Another of the most common strains found in your large intestine, and also found in the oral cavity and vagina. It is often added to various milk-based drinks, yogurt, infant formula, and nutritional supplements available in over 30 countries, and is well-documented to support gut health and digestion.

Floradapt™ Cardio

A double-blind, randomized, placebo-controlled, prospective study demonstrated that Floradapt Cardio helps support: 4

  • Healthy total cholesterol*
  • Healthy LDL cholesterol*
  • Healthy oxidized LDL cholesterol*

A randomized, double-blind, placebo-controlled, parallel-arm trial showed that Floradapt Cardio helps support: 5

  • Healthy LDL-C, total cholesterol, and HDL-C levels*
  • Healthy LDL-C/HDL-C ratio, triglycerides, and oxidized LDL levels*
  • Healthy lipid oxidation

Floradapt™ Mature Immune Defense

A dose-response, double-blind, placebo-controlled, randomized pilot trial demonstrated that Floradapt Mature Immune Defense: 6

  • Supports immune health
  • Supports a healthy immune response and immune function
  • Helps support a healthy adaptive immune system
  • Supports healthy levels of immune system cells.

In another randomized, double-blind, placebo-controlled trial, Floradapt Mature Immune Defense  was shown to:7

  • Support healthy levels of Immunoglobulin A (IgA), one of the markers of healthy immune function.
  • Supports immune health and enhances immune function.

A double-blind, randomized, placebo-controlled trial demonstrated that Floradapt Mature Immune Defense supports: 8

  • Healthy levels of CRP—a marker of inflammatory health
  • Healthy levels of cholesterol

1Lorenzo-Zuniga V, et al. World J Gastroenterol. 2014 Jul 14;20(26):8709–16.
2Barraza-Ortiz DA, et al. Dig Dis. 2021;39(3):294–300.
3Cano-Contreras A.D, et al. J Clin Gasteroenterol. 2020;0(0):1–7.
4Fuentes M, et al. Br J Nutr. 2012 May 28;109(10):1866–72.
5Fuentes M, et al. Mediterranean J of Nutr & Metabolism. 2016;9(2):125–35.
6Mane J, et al. Nutr Hosp. 2011;26(1):228–35.
7Bosch M, et al. Nutr Hosp. 2012;27(2):504–9.
8Bosch Gallego M, et al. Nutr Hosp. 2011;26(3):642–45.

*Supports healthy levels of cholesterol already within the normal range.

Product Quality

  • Manufactured to exacting standards using highest quality raw materials
  • Produced in accordance with our strict Standard Operating Procedures (SOPs) that meet or exceed those set by the FDA’s Good Manufacturing Practices
  • Every batch tested to verify purity and potency specifications are met
  • Quality assured with our Triple-Testing Philosophy™
  • Backed by our 100% satisfaction guarantee

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