Item #SPG01

Dr. Drew Sinatra

Gut Restore Advanced

Maximum strength microbiome probiotic delivers 11 hardy strains for more regularity, less digestive upset, AND a boost in mood

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Additional Product Details

Plant-based, MAX strength probiotic tackles your toughest gut concerns

Soil-based organisms

11 broad-spectrum strains

Clean, vegetarian

Doctor formulated

11 diverse multi strains

11 diverse multi strains

Blend of soil-based organisms (SBOs), yeast-, and lactic acid-based strains helps restore balance for less gas, stomach upset, and discomfort.

SMART-Release delivery

SMART-Release delivery

13 billion live probiotics get delivered to your intestines using SMART-Release technology—the most innovative system there is.

Clean, plant-based formula

Clean, plant-based formula

Vegetarian and formulated without artificial sweeteners, preservatives, flavors, and colors. Gluten-, dairy-, and soy-free, without shellfish, fish, tree nuts, peanuts, and eggs.

Arrives alive, ready to work

Arrives alive, ready to work

The number of live organisms on the bottle is what’s alive in your bottle even on the last day of expiration.

You NEED the microorganisms that live in the soil… but modern mass farming and our antiseptic fear of “germs” have stripped us of these natural protectors.

Our guts are missing out on the bacteria that lives in soil and thrives in your gut. You get three highly beneficial types of soil-based organisms (SBOs) for optimum microbiome support including B. subtilis DE111 and B. coagulans LactoSpore, usually missing from other formulas.

Lactic acid-based strains are absolutely essential because they help maintain a healthy flora balance by crowding out unfriendly bacteria.

Every dose includes six advanced, numbered probiotic strains of Bifidobacteria and Lactobacilli—two beneficial inhabitants found in your GI tract and absolutely essential in a broad-spectrum formula.

Even as recently as 20 years ago, most people thought a healthy bacteria balance was all that was needed to maintain gut health.

...But now we know that a healthy yeast balance is just as important because it helps crowd out the undesirable yeast you DON’T want in your gut. You’ll get two of the top yeast-based strains— S. boulardii and S. cerevisiae.

Fermented foods are great for the gut—but who wants to eat sauerkraut, kombucha, and kimchi for days upon days?

A unique blend of fermented whole food botanicals—organic turmeric, organic ginger, and chlorella—come together to support the work of the probiotics. Something you won’t find in ordinary probiotics!

Soil-based organisms (SBOs)

Lactic acid-based strains



Meet Dr. Drew Sinatra, Practicing Board-Certified, Naturopathic Doctor

Gut Restore Advanced was created by Dr. Drew Sinatra, a board-certified, naturopathic doctor who specializes in digestive health and is one of the leaders of America’s new generation of “green medicine” practitioners. He holds a Doctorate in Naturopathic Medicine from Bastyr University, America’s top naturopathic and integrative medical university. As a dad himself, he knows exactly what he wants and doesn’t want for his own family, and he uses those same principles in the LifeBiome formulations he brings to his patients and now you.

Dr. Sinatra

Dr. Drew Sinatra

Vision Essentials Gold Gut Restore Probiotic
Eyedrate Gut Restore Advanced Probiotic
Forward Gold Daily Regimen Gut Prep



Serving Size

1 Daily Capsule
1 Daily Capsule
2 Daily Capsules

Ingredient Highlight

6B CFU, 11 soil, lactic acid, and yeast strains with fermented botanicals
13B CFU, 11 soil, lactic acid, and yeast strains with fermented botanicals
Five plant-based digestive enzymes plus Mucosave, ginger, and turmeric


Everyday support for constipation, diarrhea, and gut discomfort
Extra strength support for diarrhea, constipation, gut discomfort + MOOD
Breaks down hard-to-digest foods plus reduces abdominal discomfort, occasional indigestion, and feelings of bloating in just 2 days

Shelf Stable

18 months without refrigeration; live probiotics listed at time of expiration
18 months without refrigeration; live probiotics listed at time of expiration
24 months without refrigeration

Allergen Friendly

Soy-, Dairy-, Gluten-, Egg-, Shellfish-, Peanut-Free
Soy-, Dairy-, Gluten-, Egg-, Shellfish-, Peanut-Free
Soy-, Dairy-, Gluten-, Egg-, Shellfish-, Peanut-Free



Ingredients and Dosage

Doctor's Suggested Use: Take 1 capsule daily with a meal.

Serving Size: 1 Vegetarian Capsule
Servings Per Container: 30

Ingredient % DV
Microbiome Probiotic Blend (145 mg)
  Soil-Based Probiotics
B. coagulans MTCC 5856 (LactoSpore®),
B. subtilis (DE111®), B. clausii SNZ 1971 MTCC 5980

  Lactic Acid-Based Probiotics
B. lactis (HN019™), B. bifidum DSM 22892,
B. longum DSM 16603, L. acidophilus DSM 21717,
L. plantarum LMG P-21021, L. rhamnosus GG ATCC 53103

  Yeast-Based Probiotics
S. boulardii CNCM I-3799,
S. cerevisiae CNCM l-3856
13 billion CFU +
Fermented Botanicals
Organic turmeric, organic ginger, chlorella
150 mg +
*Daily Value (DV) not established

Other ingredients: Hypromellose, microcrystalline cellulose, maltodextrin, rice hulls, gellan gum, silica

Precautions: Consult a health care practitioner if you are pregnant or nursing, have a serious medical condition, or use any medications.

Keep out of reach of children.

  • Gluten Free

  • Dairy Free

  • Soy Free

  • Vegetarian

  • Egg Free

  • Peanut Free

DE111® is a registered trademark of Deerland Enzymes, Inc.
LactoSpore® is a registered trademark of Sabinsa Corporation.
HN019™ is a trademark of Fonterra™ Limited.
Due to the nature of these ingredients, color variation may occur.

Science and Quality

Soil-Based Blend

Gut Restore Advanced contains a Soil-Based Probiotic Blend consisting of three spore-forming, soil-based probiotic strains:

  1. Bacillus coagulans MTCC5856 (LactoSpore®):

Two particular studies have shown positive effects with 2 billion CFU using LactoSpore B. coagulans. One randomized, double-blind, placebo-controlled trial with 31 participants showed that 2 billion CFU of LactoSpore® B. coagulans reduced GI discomfort compared to placebo over a 90-day study period with individuals also reporting an improvement in quality of life.1

In another randomized, double-blind, placebo-controlled trial with 40 individuals, results showed that supplementation with LactoSpore B. coagulans led to an improvement in mood and support of mental health, a reduction in gastrointestinal discomfort, and an improvement in digestive quality of life.2

  1. Bacillus subtilis (DE111®):

In a double-blind, placebo-controlled randomized study, 50 adults took 1 billion CFU of DE111 B. subtilis daily for 90 days. The subjects consuming the B. subtilis saw a significant increase in normal stools based on scoring according to the Bristol Stool Chart by days 75–90 compared to placebo. The results indicate that DE111 consumption promotes stool regularity, digestive health, improved bowel movements and healthy intestinal transit while improving occasional constipation or diarrhea.3

  1. Bacillus clausii SNZ-1971:

B. clausii is a spore-forming bacterial strain that is found in soil and in the GI tract. The strain is specifically found in alkaline nitrate-rich soil, where it converts nitrate to nitrite.

Yeast-Based Blend

Natural strains of yeast are found in the soil, surface of plants, and in insects and warm-blooded animals. Gut Restore Advanced provides two unique yeast-based probiotics of the Saccharomyces genera, which are normal components of the gut microbiome.

  1. Saccharomyces cerevisiae CNCM I-3856:

The Human Microbiome Project cohort conducted a study on 317 human stool samples from 147 volunteers. Results showed that S. cerevisiae was the most prominent fungal genera present in the samples with a prevalence of 92.2%. This suggests that S. cerevisiae is a commensal in the human GI tract and part of the core gut mycobiome.4

  1. Saccharomyces boulardii DBVPG 6763 (BiOOtic®): 

S. boulardii is a common fungal inhabitant in the GI tract and plays an important role in supporting intestinal health. This genome-sequenced yeast-based S. boulardii strain is called BiOOtic. BiOOtic is prestigiously produced in Sant’Antonino, Switzerland with halal, kosher, and non-GMO project verified certifications.

Lactic Acid-Based Blend

Gut Restore Advanced contains a blend of three Bifidobacteria and three Lactobacilli strains, featuring the clinically researched and genotypically documented strain Bifidobacterium lactis HN019™ (shown to be bile and acid resistant) plus Lactobacillus rhamnosus GG.

  1. Bifidobacterium lactis HN019™:

One triple-blind, randomized, placebo-controlled study on 100 adults consuming either 1.8 Billion CFU B. lactis HN019, 17.2 Billion CFU B. lactis HN019 or placebo found a significant decrease in gut transit time for the B. lactis groups. Subjects in the B. lactis groups also reported significant improvement in gastrointestinal symptoms such as regurgitation, flatulence, nausea, irregular bowel movements, abdominal pain, gurgling, and constipation.5

Another 4-week randomized, double-blind, placebo-controlled study found that consumption of varying levels of B. lactis HN019 including 1 Billion CFU daily helped maintain a balanced environment in the gastrointestinal tract and the overall bifidobacteria and lactobacilli population increased as well.6

  1. Bifidobacterium bifidum BB01 (DSM 22892)
  2. Bifidobacterium longum BL03 (DSM 16603)
  3. Lactobacillus acidophilus LA02 (DSM 21717)
  4. Lactobacillus plantarum LP01 (LMG P-21021)
  5. Lactobacillus rhamnosus GG ATCC 53103

Fermented Botanical Blend

The Fermented Botanical Blend includes a trusted brand of fermented botanicals called FermaPro® which works in conjunction with the Gut Restore Advanced probiotic blend to provide complete and comprehensive support for and coverage of the microbiome. The fermentation process used in the Fermented Botanical Blend helps enrich foods by fermenting them with beneficial bacteria, a practice that dates back thousands of years.7

UNIQUE DELIVERY TECHNOLOGY: DRcaps® vegetarian capsules

DRcaps vegetarian SMART-Release capsules have been scientifically studied to be acid-resistant and protect against early disintegration in the stomach. In 2013, an independent research laboratory (Bio-Images Research, in Glasgow, Scotland) conducted a human in-vivo study to evaluate the disintegration behavior of the DRcaps in human subjects.

Approximately 30 minutes after consuming a small meal, eight subjects swallowed one DRcaps filled with radio label and 150 mL of room temperature water. Gamma scintigraphy images showed that disintegration occurred approximately 45 minutes later than the immediate release capsules of approximately 5 minutes. The mean time of onset release was 52 minutes, right as the capsules were about to leave the stomach. Most of the release completion occurred in the small intestine. 8

In a separate in-vitro disintegration test of DRcaps with simulated gastric fluid of pH 1.2, capsules resisted rupture for at least 30 minutes (DRcaps Capsules Performance Characteristics). This simulation of gastric and intestinal fluids proved that the capsules would release at different points based on the surrounding pH level.8

1 Majeed M, et al. World J Microbiol Biotechnol. 2016; Apr;32(4):60.
2 Majeed M, et al. Food & Nutrition Research. 2018; 62. 10.29219.
3 Cuentas A M, et al. J Prob Health 2017; 5: 189.
4 Nash AK, et al. Microbiome. 2017; 5. 10.1186.
5 Waller PA, et al. Scandinavian Journal of Gastroenterology. 2011; 46. 1057–64.
6 Ahmed M, et al. The Journal of Nutrition, Health & Aging. 2007; 11. 26–31.
7 Chilton, SN. Nutrients 2015; 7. 390–404.
8 Unpublished. DRCaps® Capsules Achieve Delayed Release Properties for Nutritional Ingredients in Human Clinical Study. 2014.

Product Quality

  • Manufactured to exacting standards using highest quality raw materials
  • Produced in accordance with our strict Standard Operating Procedures (SOPs) that meet those set by the FDA’s Good Manufacturing Practices
  • Every batch tested to verify purity and potency specifications are met
  • Quality assured with our Triple-Testing Philosophy™
  • Backed by our 100% satisfaction guarantee

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