Item #LDG01

Dr. Drew Sinatra

LifeBiome Daily Gut Bundle

3-step digestive supplement regimen provides comprehensive gut microbiome support

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Prepare, Restore, and Soothe the Gut

LifeBiome® Daily Gut Bundle features Dr. Drew Sinatra’s top three choices for total gut health bundled all together for one low price! You get his Gut Prep Digestive Enzymes, Gut Restore Advanced Extra Strength Probiotic, and Gut Soothe Digestive Relief Complex to tackle your gut health from all angles. These plant-based digestive health supplements are formulated by Dr. Drew Sinatra, a practicing, board-certified naturopathic physician to address the health of your whole body by first addressing the health of your gut.

These supplements were created to work together as part of a three-step process for comprehensive gut microbiome support. Taken together, they help prepare and balance the gut’s microbiome for optimal digestion, and provide soothing relief from gas, bloating and occasional indigestion and irregularity. You can rest assured each product is vegetarian and gluten free, gentle on your stomach, and non-habit forming, and contains no artificial preservatives, flavors, colors, or sweeteners.

Step 1: LifeBiome Gut Prep Digestive Enzymes

Gut Prep features clinically validated DigeZyme® enzymes to help make the digestion of hard-to-digest foods like fats, proteins, carbs, and milk easier, resulting in less abdominal discomfort and bloating. Plus, clinically validated MucoSave helps relieve occasional gas and indigestion as well, with a 70% improvement in uncomfortable gastrointestinal symptoms! You also get organic ginger and turmeric for healthy digestion.

Step 2: LifeBiome Gut Restore Advanced Probiotic

Dr. Drew Sinatra recommends a probiotic for virtually every patient he sees—there is nothing more critical than restoring balance to the microbiome in your gut! Gut Restore Advanced delivers 13 billion live organisms for maximum strength digestive support, less digestive upset and more regularity. Plus, you get support for less daytime drowsiness and a boost in mood.

Most ordinary probiotics contain just a few common bacteria strains. But Gut Restore Advanced provides these multiple types of flora your gut needs to thrive along with fermented botanicals to support the actions of the probiotics:

1. SOIL-BASED PROBIOTICS: These spores are incredibly resilient, so they can survive the harsh acid in your stomach. The superstar soil-based strain, B. coagulans MTCC 5856 LactoSpore®, has been shown to improve gas and bowel movements, and as a result, mood. Plus, it has prebiotic-like effects, helping to increase the levels of Bifidobacteria found in the colon.

2. LACTIC ACID-BASED PROBIOTICS: This includes Lactobacilli and Bifidobacteria, the probiotic strains most people are familiar with because they are important for maintaining healthy microbial flora.

3. YEAST-BASED PROBIOTICS: Beneficial yeast strains are critical for establishing balance in the GI tract, and for crowding out undesirable yeast you DON’T want. Gut Restore Advanced delivers S. boulardii and S. cerevisiae—two of the helpful yeasts found in your GI tract.

Step 3: LifeBiome Gut Soothe Digestive Relief Complex

Gut Soothe Digestive Relief Complex is gentle on your stomach and delivers support to balance, nourish, and soothe the gut. Each packet helps alleviate occasional bloating, nausea, and stomach upset. Plus, it gives you glutamine, ginger, and aloe along with clinically validated GutGard® Licorice Extract and PreticX, a well-tolerated prebiotic fiber that nourishes the growth of healthy gut flora—without the bloating or upset that can come from traditional fibers.

Now you can experience real relief, no matter where you are. It takes just seconds to tear open one of these convenient, “stay fresh” on-the-go daily packets, pour into hot or cold water, and enjoy soothing relief! The delicious apple-pear-ginger flavor is soothing and refreshing.

Taken together daily, the digestive supplements in LifeBiome Gut Daily Bundle deliver comprehensive gut health support…at great savings.

Ingredients and Dosage

1. Gut Prep Digestive Enzymes

Doctor's Suggested Use: Take 1 vegan capsule with each of your 2 largest daily meals.

Serving Size: 1 Vegan Capsule
Servings Per Container: 60

Ingredient Amount Per Serving % DV
Mucosave FG
Prickly Pear Extract (Opuntia ficus indica cladode)
and Olive Extract (Olea europaea leaf)
200 mg *
DigeZyme® Enzyme Blend
150 mg *
Carbohydrate Digestive Enzyme – Alpha-amylase (A. oryzae)
3600 DU *
Protein Digestive Enzyme – Neutral Protease (B. subtilis)
900 PC *
Lactose Digestive Enzyme – Lactase (A. oryzae)
600 ALU *
Fiber and Complex Carbohydrate Digestive Enzyme
Cellulase (T. longibrachiatum)

165 CU *
Fat Digestive Enzyme – Lipase (R. oryzae)
30 FIP *
Organic Ginger Powder (rhizome)
75 mg *
Organic Turmeric Powder (rhizome)
75 mg *
*Daily Value (DV) not established

Other ingredients: Hypromellose, maltodextrin, microcrystalline cellulose, rice flour

Precautions: Consult a health care practitioner if you are pregnant or nursing, have a serious medical condition, or use any medications.

Keep out of reach of children.

Gluten Free


Dairy Free

Soy Free

GMO Free

Mucosave FG is a trademark of Bionap SRL.
DigeZyme® is a registered trademark of Sabinsa Corporation.

2. Gut Restore Advanced

Doctor's Suggested Use: Take 1 capsule daily with a meal.

Serving Size: 1 Vegetarian Capsule
Servings Per Container: 30

Ingredient % DV
Microbiome Probiotic Blend (145 mg)
   Soil-Based Probiotics
B. coagulans MTCC 5856 (LactoSpore®),
B. subtilis (DE111®), B. clausii SNZ 1971 MTCC 5980

   Lactic Acid-Based Probiotics
B. lactis (HN019), B. bifidum DSM 22892,
B. longum DSM 16603, L. acidophilus DSM 21717,
L. plantarum LMG P-21021, L. rhamnosus GG ATCC 53103

   Yeast-Based Probiotics
S. boulardii DBVPG 6763 (BiOOtic),
S. cerevisiae CNCM l-3856
13 billion CFU +
Fermented Botanicals
Organic turmeric, organic ginger, chlorella
150 mg +
+ Daily Value (DV) not established

Other ingredients: Hypromellose, microcrystalline cellulose, maltodextrin, rice hulls, gellan gum, silica

Precautions: Consult a health care practitioner if you are pregnant or nursing, have a serious medical condition, or use any medications.

Keep out of reach of children.

Gluten Free

Dairy Free

Soy Free


DE111 ® is a registered trademark of Deerland Enzymes, Inc.
LactoSpore® is a registered trademark of Sabinsa Corporation.
HN019 is a trademark of Fonterra Limited.
BiOOtic is a trademark of Gnosis SpA.
Due to the nature of these ingredients, color variation may occur.

3. Gut Soothe Digestive Relief Complex

Doctor's Suggested Use: Mix one stick pack into 8-10 fl. oz. of hot or cold water. More water may be added for your taste preference.

Serving Size: 1 Stick Pack (9 grams)
Servings Per Container: 15

Ingredient Amount Per Serving % DV
Calories 10   
Total Carbohydrates 4 g 1%
Glutamine (from fermentation) 3 g *
Prebiotic Xylooligosaccharide (PreticX ®) 2.5 g *
Deglycyrrhizinated Licorice Extract ( Glycyrrhiza glabra, root) (GutGard®)
150 mg *
Aloe Vera Extract (Aloe barbadensis, inner leaf gel) 100 mg *
Ginger Extract ( Zingiber officinale, rhizome) 50 mg *
* Daily Value (DV) not established.

Other ingredients: Malic acid, natural flavor, organic tapioca maltodextrin, silica, stevia leaf extract

Precautions: Consult a health care practitioner if you are pregnant or nursing, have a serious medical condition, or use any medications.

Keep out of reach of children.

Gluten Free

Dairy Free

Soy Free


Due to the nature of these ingredients, color variation may occur.
This package is sold by weight and not by volume.

PreticX® is a trademark of AIDP, Inc.
GutGard® is a trademark of Natural Remedies PVT. LTD.

Science and Quality

1. Gut Prep Digestive Enzymes

DigeZyme® Enzyme Blend

DigeZyme is a unique, clinically validated vegan, non-GMO multi-enzyme complex of five digestive enzymes to help digest foods for healthy, comfortable digestion. Plus, DigeZyme is shown to support muscle comfort and soreness after exercise.

Alpha-Amylase: helps break down carbohydrates. Amylase functions over a broad range of pH (3–8), which indicates it will help start to break down starches in the stomach after a meal. However, most carbohydrate digestion occurs in the intestines, where the enzymes will continue to work.

Cellulase: breaks down cellulose and chitin. It helps to free nutrients in fruits and vegetables.

Lipase: breaks down fat into glycerol and fatty acids.

Protease: breaks down protein and peptides.

Lactase: breaks down milk lactose, which is especially important for those with lactose intolerance.

Two randomized double-blind clinical studies have been conducted on DigeZyme. One shows beneficial effects on digestive symptoms including reduced feelings of fullness, bloating, abdominal discomfort, nausea, and occasional indigestion. The other study shows benefits for parameters of muscle discomfort, soreness, and tenderness, following exercise in healthy males.1

MucoSave FG, Prickly Pear Extract (Opuntia ficus indicacladodes) and Olive Extract (Olea europaea leaf)

Mucosave FG is a blend of two herbal extracts containing polysaccharides of prickly pear cladodes (Opuntia ficus indica (L.)) and biophenols of olive leaves (Olea europaea (L.)). It’s clinically validated to support gastrointestinal health and help with abdominal discomfort in as little as two days.

In a randomized, double-blind, placebo-controlled study, participants with gastrointestinal discomfort were given either 400 mg of Mucosave FG or a placebo daily for 8 weeks. Gastrointestinal symptoms were evaluated by the Gastrointestinal Quality of Life Index (GIQLI) and GSAS. GIQLI analysis shows significant improvements in abdominal discomfort, sense of fullness, flatulence, bowel movements, reflux, and nausea in just 4 weeks compared to placebo. Total GSAS scores significantly improved after 4 weeks of treatment showing that Mucosave significantly improves gastrointestinal symptoms compared to placebo. In fact, distress caused by GI discomfort was significantly reduced compared to placebo and compared to baseline, distress dropped by 85% and 77% after 4 and 8 weeks of treatment. Even better, participants started experiencing relief in as early as two days.2

Organic Ginger Powder

Ginger has been historically used for thousands of years in both Ayurvedic and Chinese tradition to support digestive health.

Organic Turmeric Powder

Turmeric has been used for centuries in South Asia as a spice in food or mixed into a paste used for skin benefits. Ayurvedic practices consider turmeric to be an essential nutrient with numerous benefits.

1 Majeed M, et al. Sports Nutr Ther. 2016;1(3) and Majeed M, et al. J Med Food. 2018;21(11):1120–1128.
2 Malfa, GA, et al. 2020.

2. Gut Restore Advanced

Soil-Based Blend

Gut Restore Advanced contains a Soil-Based Probiotic Blend consisting of three spore-forming, soil-based probiotic strains:

  1. Bacillus coagulans MTCC5856 (LactoSpore®):

Two particular studies have shown positive effects with 2 billion CFU using LactoSpore B. coagulans. One randomized, double-blind, placebo-controlled trial with 31 participants showed that 2 billion CFU of LactoSpore® B. coagulans reduced GI discomfort compared to placebo over a 90-day study period with individuals also reporting an improvement in quality of life.1

In another randomized, double-blind, placebo-controlled trial with 40 individuals, results showed that supplementation with LactoSpore B. coagulans led to an improvement in mood and support of mental health, a reduction in gastrointestinal discomfort, and an improvement in digestive quality of life.2

  1. Bacillus subtilis (DE111®):

In a double-blind, placebo-controlled randomized study, 50 adults took 1 billion CFU of DE111 B. subtilis daily for 90 days. The subjects consuming the B. subtilis saw a significant increase in normal stools based on scoring according to the Bristol Stool Chart by days 75–90 compared to placebo. The results indicate that DE111 consumption promotes stool regularity, digestive health, improved bowel movements and healthy intestinal transit while improving occasional constipation or diarrhea.3

  1. Bacillus clausii SNZ-1971:

B. clausii is a spore-forming bacterial strain that is found in soil and in the GI tract. The strain is specifically found in alkaline nitrate-rich soil, where it converts nitrate to nitrite.

Yeast-Based Blend

Natural strains of yeast are found in the soil, surface of plants, and in insects and warm-blooded animals. Gut Restore Advanced provides two unique yeast-based probiotics of the Saccharomyces genera, which are normal components of the gut microbiome.

  1. Saccharomyces cerevisiae CNCM I-3856:

The Human Microbiome Project cohort conducted a study on 317 human stool samples from 147 volunteers. Results showed that S. cerevisiae was the most prominent fungal genera present in the samples with a prevalence of 92.2%. This suggests that S. cerevisiae is a commensal in the human GI tract and part of the core gut mycobiome.4

  1. Saccharomyces boulardii DBVPG 6763 (BiOOtic®):

S. boulardii is a common fungal inhabitant in the GI tract and plays an important role in supporting intestinal health. This genome-sequenced yeast-based S. boulardii strain is called BiOOtic. BiOOtic is prestigiously produced in Sant’Antonino, Switzerland with halal, kosher, and non-GMO project verified certifications.

Lactic Acid-Based Blend

Gut Restore Advanced contains a blend of three Bifidobacteria and three Lactobacilli strains, featuring the clinically researched and genotypically documented strain Bifidobacterium lactis HN019 (shown to be bile and acid resistant) plus Lactobacillus rhamnosus GG.

  1. Bifidobacterium lactis HN019:

One triple-blind, randomized, placebo-controlled study on 100 adults consuming either 1.8 Billion CFU B. lactis HN019, 17.2 Billion CFU B. lactis HN019 or placebo found a significant decrease in gut transit time for the B. lactis groups. Subjects in the B. lactis groups also reported significant improvement in gastrointestinal symptoms such as regurgitation, flatulence, nausea, irregular bowel movements, abdominal pain, gurgling, and constipation.5

Another 4-week randomized, double-blind, placebo-controlled study found that consumption of varying levels of B. lactis HN019 including 1 Billion CFU daily helped maintain a balanced environment in the gastrointestinal tract and the overall bifidobacteria and lactobacilli population increased as well.6

  1. Bifidobacterium bifidum BB01 (DSM 22892)
  2. Bifidobacterium longum BL03 (DSM 16603)
  3. Lactobacillus acidophilus LA02 (DSM 21717)
  4. Lactobacillus plantarum LP01 (LMG P-21021)
  5. Lactobacillus rhamnosus GG ATCC 53103

Fermented Botanical Blend

The Fermented Botanical Blend includes a trusted brand of fermented botanicals called FermaPro® which works in conjunction with the Gut Restore Advanced probiotic blend to provide complete and comprehensive support for and coverage of the microbiome. The fermentation process used in the Fermented Botanical Blend helps enrich foods by fermenting them with beneficial bacteria, a practice that dates back thousands of years.7

UNIQUE DELIVERY TECHNOLOGY: DRcaps® vegetarian capsules

DRcaps vegetarian SMART-Release capsules have been scientifically studied to be acid-resistant and protect against early disintegration in the stomach. In 2013, an independent research laboratory (Bio-Images Research, in Glasgow, Scotland) conducted a human in-vivo study to evaluate the disintegration behavior of the DRcaps in human subjects.

Approximately 30 minutes after consuming a small meal, eight subjects swallowed one DRcaps filled with radio label and 150 mL of room temperature water. Gamma scintigraphy images showed that disintegration occurred approximately 45 minutes later than the immediate release capsules of approximately 5 minutes. The mean time of onset release was 52 minutes, right as the capsules were about to leave the stomach. Most of the release completion occurred in the small intestine. 8

In a separate in-vitro disintegration test of DRcaps with simulated gastric fluid of pH 1.2, capsules resisted rupture for at least 30 minutes (DRcaps Capsules Performance Characteristics). This simulation of gastric and intestinal fluids proved that the capsules would release at different points based on the surrounding pH level.8

1 Majeed M, et al. World J Microbiol Biotechnol. 2016; Apr;32(4):60.
2 Majeed M, et al. Food & Nutrition Research. 2018; 62. 10.29219.
3 Cuentas A M, et al. J Prob Health 2017; 5: 189.
4 Nash AK, et al. Microbiome. 2017; 5. 10.1186.
5 Waller PA, et al. Scandinavian Journal of Gastroenterology. 2011; 46. 1057–64.
6 Ahmed M, et al. The Journal of Nutrition, Health & Aging. 2007; 11. 26–31.
7 Chilton, SN. Nutrients 2015; 7. 390–404.
8 Unpublished. DRCaps® Capsules Achieve Delayed Release Properties for Nutritional Ingredients in Human Clinical Study. 2014.

3. Gut Soothe Digestive Relief Complex

Glutamine: an amino acid and chief building block for the epithelial cells that line the intestinal wall. Laboratory studies suggest glutamine may help promote the tight junctions between cells of the intestinal wall, thereby supporting the health of the intestinal barrier.1 A healthy intestinal barrier allows beneficial nutrients to pass through into the bloodstream for overall good health.2

PreticX® XOS Fiber: A unique source of non-digestible fiber from non-GMO corn. Provides beneficial gut bacteria with energy, thereby promoting the growth of beneficial gut flora, particularly bifidobacteria.3,4,5

  • Research suggests XOS strongly fosters the growth of bifidobacteria, one of the beneficial bacteria in the gut.4,5
  • Unlike other sources of plant fiber, it requires a lower dose for benefits and has been found to be better tolerated by not promoting excessive cramping, gas, or bloating.4

GutGard: This special form of licorice extract is shown in clinical research to reduce occasional bloating, belching, and feeling of fullness and nausea after meals.6 It provides antioxidant protection from free radicals and oxidative stress.7

  • In a double-blind, placebo-controlled study, 50 participants who took GutGard for 30 days saw a reduction in bloating, belching, and nausea as well as reduced feelings of fullness after meals.6
  • Animal studies show it supports the gastric mucosal lining and that it balances stomach acid production.7

Ginger Extract: works through the digestive tract to soothe the gut. And, laboratory studies suggest it helps support a healthy inflammatory response.8

  • Contains unique phenol and gingerol compounds which support a healthy inflammatory response in laboratory studies.

Aloe Vera Extract: supports overall gastrointestinal health.9,10 It has traditionally been used for its soothing properties.

  • Contains antioxidant polyphenols that provide protection from oxidative stress and free radicals.11,12,13

1 Li N, Neu J. J Nutr. 2009;139(4): 710–14.
2 Scheppach W, et al. Gut 1996;38(6): 878–85.
3 Yang J, et al Frontiers in Physiology 2015;6: 1–11.
4 Finegold SM, et al. Food & Function 2014;5: 436–45.
5 Chung Y-C, et al. Nutr Res. 2007;27(12): 756–61.
6 Raveendra KR, et al. Evid Based Comp and Alt Med. 2012;2012: 1–9.
7 Mukherjee M, et al. Indian J Exp Bio. 2012;2012: 1–9.
8 Breemen RB, et al. Fitoterapia 2011;82(1): 38–43.
9 Pogribna M, et al. Letters in App Microbiol. 2008;46(5): 575–80.
10 Keshavarzi Z, et al. Avicenna J Phytomed 2014; 4(2): 137–43.
11 Nejatzadeh-Barandozi F. Organic and Medicinal Chemistry Letters 2013;3(1): 1–8.
12 Prueksrisakul T, et al. J Comp and Integ Med. 2015;12(2): 159—64.
13 Rajasekaran S, et al. Pharmacological Reports 2005;57: 90–96.

Product Quality

  • Manufactured to exacting standards using highest quality raw materials
  • Produced in accordance with our strict Standard Operating Procedures (SOPs) that meet or exceed those set by the FDA’s Good Manufacturing Practices
  • Every batch tested to verify purity and potency specifications are met
  • Quality assured with our Triple-Testing Philosophy
  • Backed by our 100% satisfaction guarantee

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