Probiotic Advantage Daily Care

Science and Quality

Probiotic Advantage Daily Care contains a Soil-Based Probiotic Blend consisting of three spore-forming, soil-based probiotic strains:

1. Bacillus coagulans MTCC 5856 (LactoSpore^®):

Two particular studies have shown positive effects with 2 billion CFU using LactoSpore^® B. coagulans. One randomized, double-blind, placebo-controlled trial with 31 participants showed that 2 billion CFU of LactoSpore B. coagulans reduced GI discomfort compared to placebo over a 90-day study period with individuals also reporting an improvement in quality of life.¹

In another randomized, double-blind, placebo-controlled trial with 40 individuals, results showed that supplementation with LactoSpore B. coagulans led to an improvement in mood and support of mental health, a reduction in gastrointestinal discomfort, and an improvement in digestive quality of life.²

2. Bacillus subtilis (DE111^®):

In a double-blind, placebo-controlled randomized study, 50 adults took 1 billion CFU of DE111 B. subtilis daily for 90 days. The subjects consuming the B. subtilis saw a significant increase in normal stools based on scoring according to the Bristol Stool Chart by days 75–90 compared to placebo. The results indicate that DE111 consumption promotes stool regularity, digestive health, improved bowel movements and healthy intestinal transit while improving occasional constipation or diarrhea.³

3. Bacillus clausii SNZ-1971:

B. clausii is a spore-forming bacterial strain that is found in soil and in the GI tract. The strain is specifically found in alkaline nitrate-rich soil, where it converts nitrate to nitrite.

Yeast-Based Blend

Natural strains of yeast are found in the soil, surface of plants, and in insects and warm-blooded animals. Daily Care provides two unique yeast-based probiotics of the Saccharomyces genera, which are normal components of the gut microbiome.

1. Saccharomyces cerevisiae CNCM I-3856:

The Human Microbiome Project cohort conducted a study on 317 human stool samples from 147 volunteers. Results showed that S. cerevisiae was the most prominent fungal genera present in the samples with a prevalence of 92.2%. This suggests that S. cerevisiae is a commensal in the human GI tract and part of the core gut mycobiome.⁴

2. Saccharomyces boulardii DBVPG 6763 (BiOOtic^®):

S. boulardii is a common fungal inhabitant in the GI tract and plays an important role in supporting intestinal health. This genome-sequenced yeast-based S. boulardii strain is called BiOOtic^®. BiOOtic is prestigiously produced in Sant’Antonino, Switzerland with halal, kosher, and non-GMO project verified certifications.

Lactic Acid-Based Blend

Daily Care contains a blend of three Bifidobacteria and three Lactobacilli strains, featuring clinically researched and genotypically documented strain Bifidobacterium lactis HN019^™ (shown to be bile and acid resistant) plus Lactobacillus rhamnosus GG.

1. Bifidobacterium lactis HN019^™:

One triple-blind, randomized, placebo-controlled study on 100 adults consuming either 1.8 Billion CFU B. lactis HN019, 17.2 Billion CFU B. lactis HN019 or placebo found a significant decrease in gut transit time for the B. lactis groups. Subjects in the B. lactis groups also reported significant improvement in gastrointestinal symptoms such as regurgitation, flatulence, nausea, irregular bowel movements, abdominal pain, gurgling, and constipation.⁵

Another 4-week randomized, double-blind, placebo-controlled study found that consumption of varying levels of B. lactis HN019 including 1 Billion CFU daily helped maintain a balanced environment in the gastrointestinal tract and the overall bifidobacteria and lactobacilli population increased as well.⁶

2. Bifidobacterium bifidum BB01 (DSM 22892)
3. Bifidobacterium longum BL03 (DSM 16603)
4. Lactobacillus acidophilus LA02 (DSM 21717)
5. Lactobacillus plantarum LP01 (LMG P-21021)
6. Lactobacillus rhamnosus GG ATCC 53103

Fermented Botanical Blend

The Fermented Botanical Blend includes a trusted brand of fermented botanicals called FermaPro^® which works in conjunction with the Daily Care probiotic blend to provide complete and comprehensive support for and coverage of the microbiome. The fermentation process used in the Fermented Botanical Blend helps enrich foods by fermenting them with beneficial bacteria, a practice that dates back thousands of years.⁷

UNIQUE TECHNOLOGY: DRcaps^® vegetarian capsules

DRcaps vegetarian SMART-Release capsules have been scientifically studied to be acid-resistant and protect against early disintegration in the stomach. In 2013, an independent research laboratory (Bio-Images Research, in Glasgow, Scotland) conducted a human in-vivo study to evaluate the disintegration behavior of the DRcaps in human subjects.

Approximately 30 minutes after consuming a small meal, eight subjects swallowed one DRcaps filled with radio label and 150 mL of room temperature water. Gamma scintigraphy images showed that disintegration occurred approximately 45 minutes later than the immediate release capsules of approximately 5 minutes. The mean time of onset release was 52 minutes, right as the capsules were about to leave the stomach. Most of the release completion occurred in the small intestine. ⁸

In a separate in-vitro disintegration test of DRcaps with simulated gastric fluid of pH 1.2, capsules resisted rupture for at least 30 minutes (DRcaps Capsules Performance Characteristics). This simulation of gastric and intestinal fluids proved that the capsules would release at different points based on the surrounding pH level.⁸

¹ Majeed M, et al. World J Microbiol Biotechnol. 2016; Apr;32(4):60.
² Majeed M, et al. Food & Nutrition Research. 2018; 62. 10.29219.
³ Cuentas A M, et al. J Prob Health 2017; 5: 189.
⁴ Nash AK, et al. Microbiome. 2017; 5. 10.1186.
⁵ Waller PA, et al. Scandinavian Journal of Gastroenterology. 2011; 46. 1057–64.
⁶ Ahmed M, et al. The Journal of Nutrition, Health & Aging. 2007; 11. 26–31.
⁷ Chilton, S. N. Nutrients 2015; 7. 390–404.
⁸ Unpublished. DRCaps^® Capsules Achieve Delayed Release Properties for Nutritional Ingredients in Human Clinical Study. 2014.

Product Quality

• Manufactured to exacting standards using highest quality raw materials
• Produced in accordance with our strict Standard Operating Procedures (SOPs) that meet those set by the FDA’s Good Manufacturing Practices
• Every batch tested to verify purity and potency specifications are met
• Quality assured with our Triple-Testing Philosophy™
• Backed by our 100% satisfaction guarantee