Item #IE201

Dr. Joseph Pergolizzi

Instaflex Extra Strength Pain Relief Cream

Fast-acting, penetrating relief from everyday aches and pains of sore muscles and joints

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Rub Out Your Toughest Muscle and Joint Pain with Instaflex® Extra Strength Pain Relief Cream

Instaflex Extra Strength Pain Relief Cream delivers TWICE the menthol power of original Instaflex Pain Relief Cream, plus 2X the pain-fighting ingredients! Just like original Instaflex Pain Relief Cream, this formula contains a proprietary blend of essential oxygenated oil, but with even more menthol and a new ingredient—methyl salicylate.

These powerful ingredients work to provide temporary, extra strength relief from mild to moderate pain associated with minor arthritis, backaches, muscle aches, strains and sprains, bruises, and joint pain—all in a safe, effective, non-irritating and pleasant smelling cream.

Ancient discovery, modern clinical results

In Biblical times, stories abounded of a mysterious oil used by ancient sages. It was said to be a precious and wonderfully soothing elixir. Traditionally, this comforting oil was made by leaving an essential oil in an open vat for 20 years, allowing the sun's rays to infuse the oil with oxygen.

Today, modern science has rediscovered the power of hyper-oxygenated oil, and the oxygenation process has been shortened to just three days. Athletes in Europe have been using this oil for years, but it took leading pain expert Dr. Joseph Pergolizzi to bring it home to the U.S. and combine it with soothing menthol to create the formula for Instaflex Extra Strength Pain Relief Cream.

Instaflex Extra Strength Pain Relief Cream helps relieve pain in all the following areas:

  • Back
  • Neck
  • Shoulders
  • Fingers
  • Hands
  • Wrists
  • Knuckles
  • Hips
  • Knees
  • Feet
  • Ankles
  • Toes
  • Plus, relieves sprains and strains!

With Instaflex Extra Strength Pain Relief Cream, your daily aches and pains become more manageable—making everyday activities easier. This one-of-a-kind formula is pleasant smelling and non-greasy, which is why it’s great for daytime or nighttime use. Just rub it on where you feel the pain for fast, soothing comfort.

Instaflex Extra Strength Pain Relief Cream was formulated by internationally recognized Dr. Joseph Pergolizzi, an actively practicing physician, and highly sought-after pain relief instructor, treating patients in his advanced Florida practice. Just some of the highlights of his career include…

  • Author of over 200 peer-reviewed articles, abstracts, platform presentations, and book chapters in his areas of expertise
  • Recipient of Top Anesthesiologist & Pain Management Physician for 2018 in Naples, Florida
  • Recipient of American Health Council’s 2017 Best in Medicine Award
  • Named "One of America's Most Compassionate Doctors" and winner of the 2012 Patient’s Choice Award

Ingredients and Dosage

Uses: temporarily relieves minor aches and pains of muscles and joints associated with simple backaches, arthritis, strains, sprains, bruises

Directions: Adults and children 12 years of age and older: Apply to affected area no more than 3–4 times daily. Children under 12 years of age: Consult a doctor.

Menthol (2.5%)Topical Analgesic
Methyl Salicylate (10%)Topical Analgesic

Inactive ingredients: C13-14 Isoparaffin, Citrus Aurantium Dulcis (Orange) Oil, Ethylhexylglycerin, Eucalyptus Globulus Oil, Glyceryl Stearate, Laureth-7, Oxygenated Corn Oil, PEG-100 Stearate, Phenoxyethanol, Polyacrylamide, Polysorbate-20, Water

Warnings: For external use only. Use only as directed.

Do not use with a heating pad, it may blister skin; on open wounds or damaged skin

Ask a doctor before use if you have redness over the affected area

When using this product avoid contact with eyes; do not bandage tightly

Stop use and consult a doctor if: skin redness or excessive skin irritation develops; condition worsens or symptoms persist for more than 7 days; symptoms clear up and occur again in a few days

Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

Other information: Keep product at room temperature and humidity [59–86°F (15–30°C), 40% RH]. Do not freeze.


  • Dermatologist Tested
    Dermatologist Tested

Science and Quality

Menthol & methyl salicylate for safe, effective pain relief

Instaflex® Extra Strength Pain Relief Cream contains menthol—an effective OTC pain reliever that provides pain relief by acting as a counterirritant. This means that the sensation menthol creates replaces the pain sensation. When used topically, menthol produces feelings of coolness followed by warmth. However, it does not actually warm the skin.

Methyl salicylate, a compound naturally present in wintergreen oil, is also considered a pain-relieving counterirritant, but is thought to affect different receptors than menthol. Both ingredients were included in Instaflex Extra Strength Pain Relief because they are recognized as safe and effective for pain relief, backaches, arthritis, strains, bruises, and sprains.

Essential oils and ancient practices: How oil, oxygen, and sunshine soothe skin

In the 1950s and '60s, Professor Pierre Baranger—a member of the Pasteur Institute's scientific team—traveled throughout India studying the powers of oils. These oils were known throughout the East for their exceptional restorative virtues.

Upon further study into the soothing qualities of oils, Baranger became perplexed as to why modern doctors in the mainland cities weren't using the oils. Local healers informed him that it was because modern doctors didn't know the secret to properly preparing the oils. To truly harness its natural powers, the oil first had to be exposed to sun and open air for 20 years. Using all he had learned from the medicine men of India, Baranger was able to pioneer a process that replicates 20 years of oxygenation in just three days. This allowed him to introduce these powerful soothing oils to the West.

Dr. Pergolizzi was first introduced to the benefits of oxygenated oil while traveling through Germany. This inspired Dr. Pergolizzi to learn more about oxygenated oil, the history of its use, and how he could best incorporate it into his own pain-relief treatments.

The unique features of this oxygenated oil unlock a world of potential for both soothing and moisturizing skin.

Product Quality

  • Manufactured to exacting standards using highest quality raw materials
  • Produced in accordance with our strict Standard Operating Procedures (SOPs) that adhere to strict standards set by the FDA’s Good Manufacturing Practices
  • Every batch tested to verify purity and potency specifications are met
  • Quality assured with our Triple-Testing Philosophy™
  • Backed by our 100% satisfaction guarantee

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